Background With the discovery that more than half of human cancers harbor mutations in
chromatin proteins, deregulation of epigenetic mechanisms has been recognized a hallmark …

At each round of cell division, the DNA must be correctly duplicated and distributed between
the two daughter cells to maintain genome identity. In order to achieve proper chromosome …

To faithfully transmit genetic information, cells must replicate their entire genome before
division. This is thought to be ensured by the temporal separation of replication and …

Posttranslational modifications (PTMs) of histone proteins are important for various cellular
processes including regulation of gene expression and chromatin structure, DNA damage …

As a cell prepares to divide, its genetic material changes dramatically in both form and
function. During interphase, a dynamic interplay between DNA compartmentalization and …

The size of the intracellular structure that encloses genomic DNA–known as the nucleus in
eukaryotes and nucleoid in prokaryotes–is believed to scale according to cell size and …

De novo synthesis of a genome makes it possible to probe fundamental biological questions
that are experimentally inaccessible with traditional approaches. For example, the functions …

Summary Structural Maintenance of Chromosomes 2 (SMC2) and Structural Maintenance of
Chromosomes 4 (SMC4) are the core components of the condensin complexes, which are …

In eukaryotic cells, the spatial organization of genes within the nucleus is correlated with
their expression. However, correlation is not causa-tion. To determine how nuclear spatial …