[HTML][HTML] Absolute quantification of transcription factors reveals principles of gene regulation in erythropoiesis
MA Gillespie, CG Palii, D Sanchez-Taltavull… - Molecular cell, 2020 - cell.com
Dynamic cellular processes such as differentiation are driven by changes in the abundances
of transcription factors (TFs). However, despite years of studies, our knowledge about the …
of transcription factors (TFs). However, despite years of studies, our knowledge about the …
Targeting GATA4 for cardiac repair
MJ Välimäki, HJ Ruskoaho - IUBMB life, 2020 - Wiley Online Library
Various strategies have been applied to replace the loss of cardiomyocytes in order to
restore reduced cardiac function and prevent the progression of heart disease. Intensive …
restore reduced cardiac function and prevent the progression of heart disease. Intensive …
Quantitative and qualitative impairments in GATA2 and myeloid neoplasms
R Shimizu, M Yamamoto - IUBMB life, 2020 - Wiley Online Library
GATA2 is a key transcription factor critical for hematopoietic cell development. During the
past decade, it became clear that heterozygous germline mutations in the GATA2 gene …
past decade, it became clear that heterozygous germline mutations in the GATA2 gene …
[HTML][HTML] Liganded T3 receptor β2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production
N Hirahara, HM Nakamura, S Sasaki, A Matsushita… - PloS one, 2020 - journals.plos.org
The serum concentration of thyrotropin (thyroid stimulating hormone, TSH) is drastically
reduced by small increase in the levels of thyroid hormones (T3 and its prohormone, T4); …
reduced by small increase in the levels of thyroid hormones (T3 and its prohormone, T4); …
Arsenite suppresses the transcriptional activity of EVI1 through the binding to CCHC-type Zn finger domain
M Ogawa, Y Okamoto, S Himeno, K Suzukawa… - Biochemical and …, 2020 - Elsevier
Transcription factor EVI1 is essential for normal hematopoiesis in embryos but is aberrantly
elevated in bone marrow cells of myelodysplastic syndrome (MDS) patients. EVI1 and its …
elevated in bone marrow cells of myelodysplastic syndrome (MDS) patients. EVI1 and its …
Dynamic regulation of GATA2 in fate determination in hematopoiesis: possible approach to hPSC-derived hematopoietic stem/progenitor cells
Y Zhou, B Mao, Y Chen, Y Xue, B Chen, Y Zhang… - Blood Science, 2020 - mednexus.org
GATA2, a principal member of the GATA family, plays important roles in the generation and
maintenance of hematopoietic stem/progenitor cells. Among the three mRNA transcripts, the …
maintenance of hematopoietic stem/progenitor cells. Among the three mRNA transcripts, the …
Modelling GATA2 haploinsufficiency driven immunodeficiency and myelodysplastic syndromes/acute myeloid leukaemia
A Abdelfattah - 2020 - orca.cardiff.ac.uk
HSCs are entirely responsible for the continuous replenishment of short-lived blood cells to
preserve haematopoietic homeostasis. GATA2, a zinc-finger transcription factor, is highly …
preserve haematopoietic homeostasis. GATA2, a zinc-finger transcription factor, is highly …