Micronuclei as biomarkers of DNA damage, aneuploidy, inducers of chromosomal hypermutation and as sources of pro-inflammatory DNA in humans

M Fenech, S Knasmueller, C Bolognesi… - … Research/Reviews in …, 2020 - Elsevier
Micronuclei (MNi) are among the most widely studied biomarkers of DNA damage and
chromosomal instability in humans. They originate from chromosome fragments or intact …

Micronuclei, inflammation and auto-immune disease

M Kirsch-Volders, C Bolognesi, M Ceppi… - … Research/Reviews in …, 2020 - Elsevier
Auto-immune diseases (AUD) are characterized by an immune response to antigenic
components of the host itself. The etiology of AUD is not well understood. The available …

[HTML][HTML] Chromosomal damage measured by the cytokinesis block micronucleus cytome assay in diabetes and obesity-A systematic review and meta-analysis

B Franzke, L Schwingshackl, KH Wagner - Mutation Research/Reviews in …, 2020 - Elsevier
The percentage of people affected by overweight, obesity and/or diabetes drastically
increased within the last decades. This development is still ongoing, which puts a large part …

Micronuclei frequency in peripheral blood lymphocytes of healthy subjects living in turin (North-Italy): contribution of body mass index, age and sex

A Santovito, C Gendusa - Annals of Human Biology, 2020 - Taylor & Francis
Abstract Background: Increased micronuclei (MNi) frequencies in human lymphocytes are
an indicator of chromosome instability and could be influenced by different exogenous and …

Biomonitoring findings for occupational lead exposure in battery and ceramic tile workers using biochemical markers, alkaline comet assay, and micronucleus test …

V Kašuba, M Milić, D Želježić, M Mladinić… - Archives of Industrial …, 2020 - sciendo.com
Manufacture of lead-containing products has long been associated with various health risks.
To get an insight into the related genotoxic risks, we conducted a biomonitoring study in 50 …

Melatonin supplementation over different time periods until ageing modulates genotoxic parameters in mice

AP Damiani, G Strapazzon… - …, 2020 - academic.oup.com
The ageing process is a multifactorial phenomenon, associated with decreased
physiological and cellular functions and an increased propensity for various degenerative …

A quantitative meta-analysis of the relation between occupational benzene exposure and biomarkers of cytogenetic damage

B Scholten, J Vlaanderen, R Stierum… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: The genotoxicity of benzene has been investigated in dozens of biomonitoring
studies, mainly by studying (classical) chromosomal aberrations (CAs) or micronuclei (MN) …

Assessment of the impact of the IARC Monograph Vol. 121 on the safety of the substance styrene (FCM No 193) for its use in plastic food contact materials

EFSA Panel on Food Contact Materials, Enzymes … - EFSA …, 2020 - Wiley Online Library
Abstract The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP)
was requested by the European Commission to re‐evaluate the safety of styrene (FCM No …

Micronuclei Formation upon Radioiodine Therapy for Well-Differentiated Thyroid Cancer: The Influence of DNA Repair Genes Variants

L S. Santos, O M. Gil, S N. Silva, B C. Gomes… - Genes, 2020 - mdpi.com
Radioiodine therapy with 131I remains the mainstay of standard treatment for well-
differentiated thyroid cancer (DTC). Prognosis is good but concern exists that 131I-emitted …

Genotoxicity test methods-a tool for DNA and chromosome damage biomonitoring

N Velickova, M Milev - Serbian Archives of Medicine, 2020 - eprints.ugd.edu.mk
Nowadays is highly influenced by intense growth of various industries, high level of pollution
and other environmental factors with harmful effects on human health. Therefore …