Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …

This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) …

Synaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the
cognitive decline. An association between a polymorphism of the adenosine A2A receptor …

The levels of the astrocyte markers (GFAP, S100B) were increased unevenly in patients with
schizophrenia. Reactive astrogliosis was found in approximately 70% of patients with …

Despite extensive research into understanding synaptic mechanisms of striatal plasticity, the
functional role played by astrocytes in this region remains to be fully elucidated. It was …

Background It has been hypothesized that heteromers of adenosine A 2A receptors (A2AR)
and cannabinoid CB 1 receptors (CB1R) localized in glutamatergic nerve terminals mediate …

Psoriasis is a chronic inflammatory disease with a multifactorial origin that affects the skin. It
is characterized by keratinocyte hyperproliferation, which results in erythemato-squamous …

Background Circadian and sleep-homeostatic mechanisms regulate timing and quality of
wakefulness. To enhance wakefulness, daily consumption of caffeine in the morning and …

Adenosine is a neuromodulator that has been involved in aging and neurodegenerative
diseases as Alzheimer's disease (AD). In the present work, we analyzed the possible …

In the 1980s and 1990s, the concept was introduced that molecular integration in the Central
Nervous System could develop through allosteric receptor–receptor interactions in …