Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1)
macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by …

Advances in the understanding of the Tribbles family of pseudokinases (TRIB1, TRIB2 and
TRIB3) reveal these proteins as potentially valuable biomarkers of disease diagnosis …

Rationale: Intercellular tight junctions are crucial for correct regulation of the endothelial
barrier. Their composition and integrity are affected in pathological contexts, such as …

Dysregulated microglia are intimately involved in neurodegeneration, including Alzheimer's
disease (AD) pathogenesis, but the mechanisms controlling pathogenic microglial gene …

Rationale: Epidemiological studies have identified an associate between iron deficiency (ID)
and the use of oral contraceptives (CC) and ischemic stroke (IS). To date, however, the …

Rationale: V-domain immunoglobulin suppressor of T cell activation (VISTA) is a novel
inhibitory immune checkpoint molecule. Vsir-/-mice have exacerbated psoriasis-like skin …

Skeletal muscle atrophy is a highly-prevalent and debilitating condition that remains poorly
understood at the molecular level. Previous work found that aging, fasting, and …

The hepatitis B virus (HBV) chronically infects over 250 million people worldwide and is one
of the leading causes of liver cancer and hepatocellular carcinoma. HBV persistence is due …

Medulloblastoma (MB) is a malignant pediatric brain tumor for which new therapies are
urgently needed. We demonstrate that treatment with EPZ-6438 (Tazemetostat), an …

Nuclear factor erythroid 2-related factor 1 (NRF1), a ubiquitously expressed CNC-bZIP
transcription factor, plays a critical role in white adipocyte (WAC) biology, whereas the …