[HTML][HTML] Mode of action-based risk assessment of genotoxic carcinogens

A Hartwig, M Arand, B Epe, S Guth, G Jahnke… - Archives of …, 2020 - Springer
The risk assessment of chemical carcinogens is one major task in toxicology. Even though
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …

[HTML][HTML] New approach methods to evaluate health risks of air pollutants: Critical design considerations for in vitro exposure testing

J Zavala, AN Freedman, JT Szilagyi, I Jaspers… - International journal of …, 2020 - mdpi.com
Air pollution consists of highly variable and complex mixtures recognized as major
contributors to morbidity and mortality worldwide. The vast number of chemicals, coupled …

[HTML][HTML] RNA oxidation in chromatin modification and DNA-damage response following exposure to formaldehyde

JC Gonzalez-Rivera, MW Sherman, DS Wang… - Scientific Reports, 2020 - nature.com
Formaldehyde is an environmental and occupational chemical carcinogen implicated in the
damage of proteins and nucleic acids. However, whether formaldehyde provokes …

[HTML][HTML] Formaldehyde exposure and epigenetic effects: A systematic review

V Leso, MC Macrini, F Russo, I Iavicoli - Applied Sciences, 2020 - mdpi.com
Formaldehyde (FA) is a general living and occupational pollutant, classified as carcinogenic
for humans. Although genotoxicity is recognized as a FA mechanism of action, a potential …

Concentration characteristics of gaseous carbonyl compounds in urban houses in two different climatic zones of China and health risk assessment for schoolchildren

G Fan, J Xie, H Yoshino, H Zhang, Z Li, N Li… - Sustainable Cities and …, 2020 - Elsevier
This paper reported concentration characteristics of thirteen kinds of gaseous carbonyl
compounds (CCs) in urban houses with schoolchildren in two different climatic zones of …

Identifying the transcriptional response of Cancer and inflammation-related genes in lung cells in relation to ambient air chemical mixtures in Houston, Texas

LA Eaves, HT Nguyen, JE Rager… - … science & technology, 2020 - ACS Publications
Atmospheric pollution represents a complex mixture of air chemicals that continually interact
and transform, making it difficult to accurately evaluate associated toxicity responses …

[HTML][HTML] Reducing toxic reactive carbonyl species in e-cigarette emissions: testing a harm-reduction strategy based on dicarbonyl trapping

B de Falco, A Petridis, P Paramasivan, AD Troise… - RSC …, 2020 - pubs.rsc.org
Reducing the concentration of reactive carbonyl species (RCS) in e-cigarette emissions
represents a major goal to control their potentially harmful effects. Here, we adopted a novel …

[HTML][HTML] Understanding the Functional Impact of VOC–Ozone Mixtures on the Chemistry of RNA in Epithelial Lung Cells

LM Contreras, JC Gonzalez-Rivera… - … Health Effects Institute, 2020 - ncbi.nlm.nih.gov
BACKGROUND In this study, Dr. Lydia Contreras, a recipient of HEI's 2014 Walter A.
Rosenblith New Investigator Award, and her colleagues evaluated how exposure to …

The role of nutrition and epigenetics in environmental toxicology

A Venkatratnam, RC Fry - … Epigenetics in Toxicology and Public Health, 2020 - Elsevier
Variation in nutritional status is one of the many determinants of health or disease with large
implications for public health. As evidence for the impact of diet, animal model research has …

[PDF][PDF] COMPARATIVE STUDY BETWEEN OPTIMAL AND REDUCED FORMALIN-BASED FIXATIVE FOR NORMAL AND PATHOLOGICAL TISSUES

SS ALHAROON, NM ABDULLAH… - Asian J Pharm Clin …, 2020 - researchgate.net
Objectives: This study aims to use an alternative fixative compound with reduced
concentration of formalin to minimize the exposure and related side effects. Methods …