Autophagy is a highly conserved recycling mechanism essential for maintaining cellular
homeostasis. The pathophysiological role of autophagy has been explored since its …

The molecular signatures of epigenetic regulation and chromatin architecture are emerging
as pivotal regulators of mitochondrial function. Recent studies unveiled a complex …

Heart failure with preserved ejection fraction (HFpEF) is a major health problem without
effective therapies. This study assessed the effects of histone deacetylase (HDAC) inhibition …

Microvascular damage is a key pathological change in myocardial ischemia/reperfusion
(I/R) injury. Using a rat model of myocardial I/R, our current study has provided the first …

Long noncoding ribonucleic acids (lncRNAs) are critical regulators in various biological
processes. In the present study, we aimed to explore whether miR140-3p was involved in …

Forkhead box O (FoxO) proteins and thyroid hormone (TH) have well established roles in
cardiovascular morphogenesis and remodeling. However, specific role (s) of individual …

Pathological cardiac hypertrophy is a classical hallmark of heart failure. At the molecular
level, inhibition of histone deacetylase (HDAC) enzymes attenuate pathological cardiac …

Autophagy (greek auto: self; phagein: eating) is a highly conserved process within
eukaryotes that degrades long-lived proteins and organelles within lysosomes. Its accurate …

Ischemia reperfusion injury (I/R injury) contributes significantly to morbidity and mortality
following myocardial infarction (MI). Although rapid reperfusion of the ischemic myocardium …

The upregulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) was reported to
be involved in regulating the levels of inflammatory markers and apoptosis in macrophages …