Nonrandomized real‐world evidence to support regulatory decision making: process for a randomized trial replication project

JM Franklin, A Pawar, D Martin… - Clinical …, 2020 - Wiley Online Library
Recent legislation mandates that the US Food and Drug Administration issue guidance
regarding when real‐world evidence (RWE) could be used to support regulatory decision …

Risk for serious infection with low-dose glucocorticoids in patients with rheumatoid arthritis: a cohort study

MD George, JF Baker, K Winthrop, JY Hsu… - Annals of internal …, 2020 - acpjournals.org
Background: Low-dose glucocorticoids are frequently used for the management of
rheumatoid arthritis (RA) and other chronic conditions, but the safety of long-term use …

Comparing the 5-year diabetes outcomes of sleeve gastrectomy and gastric bypass: the National Patient-Centered Clinical Research Network (PCORNet) Bariatric …

KM McTigue, R Wellman, E Nauman, J Anau… - JAMA …, 2020 - jamanetwork.com
Importance Bariatric surgery can lead to substantial improvements in type 2 diabetes
(T2DM), but outcomes vary across procedures and populations. It is unclear which bariatric …

Association of gabapentinoids with the risk of opioid-related adverse events in surgical patients in the United States

K Bykov, BT Bateman, JM Franklin, SM Vine… - JAMA network …, 2020 - jamanetwork.com
Importance The use of gabapentinoids in multimodal postoperative analgesia is increasing;
however, when coadministered with opioids, these drugs may potentiate central nervous …

Sleep, suicide behaviors, and the protective role of sleep medicine

TM Bishop, PG Walsh, L Ashrafioun, JE Lavigne… - Sleep Medicine, 2020 - Elsevier
Abstract Objective/Background Sleep disturbance is associated with suicidal thoughts and
behaviors. The relationship of specific sleep disorders to suicide attempts is less well …

Outcomes of primary care delivery by nurse practitioners: Utilization, cost, and quality of care

CF Liu, PL Hebert, JH Douglas, EL Neely… - Health services …, 2020 - Wiley Online Library
Objective To examine whether nurse practitioner (NP)‐assigned patients exhibited
differences in utilization, costs, and clinical outcomes compared to medical doctor (MD) …

[HTML][HTML] Identifying goals of care

A Comer, L Fettig, AM Torke - The Medical Clinics of North …, 2020 - ncbi.nlm.nih.gov
As a person ages or faces serious illness, decisions about medical care become more
challenging. When cure of a disease is not possible, treatments become focused on other …

Estimates of overall survival in patients with cancer receiving different treatment regimens: emulating hypothetical target trials in the Surveillance, Epidemiology, and …

LC Petito, X García-Albéniz, RW Logan… - JAMA network …, 2020 - jamanetwork.com
Importance The Surveillance, Epidemiology, and End Results (SEER)–Medicare linked
database may provide insights into the comparative effectiveness of oncological treatments …

Association of fluoroquinolones with the risk of aortic aneurysm or aortic dissection

C Gopalakrishnan, K Bykov, MA Fischer… - JAMA internal …, 2020 - jamanetwork.com
Importance Previous observational studies have suggested that fluoroquinolones are
associated with aortic aneurysm or dissection, but these studies may be subject to …

Stress hyperglycemia and mortality in subjects with diabetes and sepsis

A Fabbri, G Marchesini, B Benazzi, A Morelli… - Critical care …, 2020 - journals.lww.com
Objectives: Poor glycemic control is associated with mortality in critical patients with
diabetes. The aim of the study was to assess the predicting value of stress hyperglycemia in …