Cytokine-targeted therapeutics for KSHV-associated disease
N Alomari, J Totonchy - Viruses, 2020 - mdpi.com
Kaposi's sarcoma-associated herpesvirus (KSHV) also known as human herpesvirus 8
(HHV-8), is linked to several human malignancies including Kaposi sarcoma (KS), primary …
(HHV-8), is linked to several human malignancies including Kaposi sarcoma (KS), primary …
Deriving immune modulating drugs from viruses—a new class of biologics
Viruses are widely used as a platform for the production of therapeutics. Vaccines containing
live, dead and components of viruses, gene therapy vectors and oncolytic viruses are key …
live, dead and components of viruses, gene therapy vectors and oncolytic viruses are key …
Chemical mutagenesis of a GPCR ligand: Detoxifying “inflammo-attraction” to direct therapeutic stem cell migration
JP Lee, R Zhang, M Yan, S Duggineni… - Proceedings of the …, 2020 - National Acad Sciences
A transplanted stem cell's engagement with a pathologic niche is the first step in its restoring
homeostasis to that site. Inflammatory chemokines are constitutively produced in such a …
homeostasis to that site. Inflammatory chemokines are constitutively produced in such a …
[HTML][HTML] Current and novel radiopharmaceuticals for imaging cardiovascular inflammation
Cardiovascular disease (CVD) remains the leading cause of death worldwide despite
advances in diagnostic technologies and treatment strategies. The underlying cause of most …
advances in diagnostic technologies and treatment strategies. The underlying cause of most …
[HTML][HTML] Identification of a novel signaling complex containing host chemokine receptor CXCR4, Interleukin-10 receptor, and human cytomegalovirus US27
CC Tu, CM O'Connor, JV Spencer - Virology, 2020 - Elsevier
Human cytomegalovirus (HCMV) is a widespread herpesvirus that establishes latency in
myeloid cells and persists by manipulating immune signaling. Chemokine receptor CXCR4 …
myeloid cells and persists by manipulating immune signaling. Chemokine receptor CXCR4 …
Cells of the Innate and Adaptive Immune Systems in Kaposi's Sarcoma
O Ngalamika, S Munsaka - Journal of immunology research, 2020 - Wiley Online Library
Kaposi's sarcoma (KS) is an angioproliferative malignancy whose associated etiologic agent
is the Kaposi's sarcoma‐associated herpesvirus (KSHV). KS is the most prevalent …
is the Kaposi's sarcoma‐associated herpesvirus (KSHV). KS is the most prevalent …
Chemokine receptors (version 2020.5) in the IUPHAR/bps guide to pharmacology database
F Bachelerie, A Ben-Baruch, AM Burkhardt… - IUPHAR/BPS Guide …, 2020 - journals.ed.ac.uk
Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on
Chemokine Receptors [431, 430, 32]) comprise a large subfamily of 7TM proteins that bind …
Chemokine Receptors [431, 430, 32]) comprise a large subfamily of 7TM proteins that bind …
[HTML][HTML] Chemokine Receptor Inhibitor vMIP-II Promoting Lymphocytes in COVID-19 Patients and Its Related Mechanism In Vitro
S Li, Y Wang, L Feng, Z Jiang, F Cong, Y Chen, Z Dai… - 2020 - europepmc.org
Abstract Coronavirus disease (COVID-19) accompanies severe immune injury as well as a
decrease and overactivation of T lymphocytes. We observed that vMIP-II, a broad-spectrum …
decrease and overactivation of T lymphocytes. We observed that vMIP-II, a broad-spectrum …
CXCR4-binding PET tracers link monocyte recruitment and endothelial injury in murine atherosclerosis
O Baba, A Elvington, M Szpakowska, D Sultan, GS Heo… - bioRxiv, 2020 - biorxiv.org
Viral macrophage inflammatory protein 2 (vMIP-II/vCCL2) binds to multiple chemokine
receptors, and vMIP-II based PET tracer (64Cu-DOTA-vMIP-II: vMIP-II tracer) accumulates at …
receptors, and vMIP-II based PET tracer (64Cu-DOTA-vMIP-II: vMIP-II tracer) accumulates at …