Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer
E3 ligases and degrons, the sequences they recognize in target proteins, are key parts of
the ubiquitin-mediated proteolysis system. There are several examples of alterations of …
the ubiquitin-mediated proteolysis system. There are several examples of alterations of …
The chromatin-binding protein PHF6 functions as an E3 ubiquitin ligase of H2BK120 via H2BK12Ac recognition for activation of trophectodermal genes
S Oh, K Boo, J Kim, SA Baek, Y Jeon, J You… - Nucleic acids …, 2020 - academic.oup.com
Epigenetic regulation is important for establishing lineage-specific gene expression during
early development. Although signaling pathways have been well-studied for regulation of …
early development. Although signaling pathways have been well-studied for regulation of …
Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules
F Hans, H Glasebach, PJ Kahle - Journal of Biological Chemistry, 2020 - ASBMB
Insoluble, hyperubiquitylated TAR DNA-binding protein of 43 kDa (TDP-43) in the central
nervous system characterizes frontotemporal dementia and ALS in many individuals with …
nervous system characterizes frontotemporal dementia and ALS in many individuals with …
A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers
P Filipčík, SL Latham, AL Cadell… - Proceedings of the …, 2020 - National Acad Sciences
The MEKK1 protein is a pivotal kinase activator of responses to cellular stress. Activation of
MEKK1 can trigger various responses, including mitogen-activated protein (MAP) kinases …
MEKK1 can trigger various responses, including mitogen-activated protein (MAP) kinases …
Novel compound variants of the AR and MAP3K1 genes are related to the clinical heterogeneity of androgen insensitivity syndrome
Y Cheng, Y Sun, Y Ji, D Jiang, G Teng… - Bioscience …, 2020 - portlandpress.com
Androgen insensitivity syndrome (AIS; OMIM 300068) is the most frequent cause of 46, XY
disorders of sex development (DSD). However, the correlation between genotype and …
disorders of sex development (DSD). However, the correlation between genotype and …
The Expression of ERK1/2 in Female Yak (Bos grunniens) Reproductive Organs
J Fan, X Han, H He, Y Luo, S Yu, Y Cui, G Xu, L Wang… - Animals, 2020 - mdpi.com
Simple Summary Extracellular signal-regulated kinases1/2 (ERK1/2) plays a significant role
in regulating the reproductive processes of mammals. The goal of our research is to …
in regulating the reproductive processes of mammals. The goal of our research is to …
A cryptic tubulin-binding domain links MEKK1 to microtubule remodelling
The MEKK1 protein is a pivotal kinase activator of responses to cellular stress. Activation of
MEKK1 can trigger various responses, including mitogen activated protein (MAP) kinases …
MEKK1 can trigger various responses, including mitogen activated protein (MAP) kinases …
Functional studies of PHF6 in trophectoderm differentiation
오성룡 - 2020 - s-space.snu.ac.kr
Epigenetic regulation is important for lineage determination during early development in
mammal. In early development, expression of specific transcription factors plays an …
mammal. In early development, expression of specific transcription factors plays an …
[引用][C] Map3k1 Loss Cooperates with BrafV600E to Drive Melanomagenesis.
LD Trucco, PA Mundra, P García-Martínez… - The Journal of …, 2020 - europepmc.org