Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

Health data are increasingly being generated at a massive scale, at various levels of
phenotyping and from different types of resources. Concurrent with recent technological …

Spaceflight is known to impose changes on human physiology with unknown molecular
etiologies. To reveal these causes, we used a multi-omics, systems biology analytical …

Elementary processes associated with ionization of liquid water provide a framework for
understanding radiation-matter interactions in chemistry and biology. Although numerous …

Despite the global rapid increase in the number of clinical trials employing chimeric antigen
receptors (CARs), no comprehensive survey of their scope, targets and design exists. In this …

Space travel presents a number of environmental challenges to the central nervous system,
including changes in gravitational acceleration that alter the terrestrial synergies between …

The upcoming exploration missions will imply a much longer duration than any of the
missions flown so far. In these missions, physiological adaptation to the new environment …

Telomere length dynamics and DNA damage responses were assessed before, during, and
after one-year or shorter duration missions aboard the International Space Station (ISS) in a …

Telomerase is perceived as an immortality enzyme that might provide longevity to cells and
whole organisms. Importantly, it is generally inactive in most somatic cells of healthy, adult …

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