Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury
after an overdose. The intracellular signaling mechanisms of APAP-induced cell death such …

Background Chemotherapy-induced peripheral neuropathy (CIPN) is regarded as one of the
most common dose-limiting adverse effects of several chemotherapeutic agents, such as …

Background and Aims Microbial dysbiosis is associated with alcohol‐related hepatitis (AH),
with the mechanisms yet to be elucidated. The present study aimed to determine the effects …

An overdose of the widely used analgesic acetaminophen (APAP) is the most common
cause of acute liver failure in the western world and hence is a clinically significant problem …

Background Paracetamol (acetaminophen) remains a leading cause of poisoning in Europe,
North America, and Australia. For over four decades, acetylcysteine has been the antidote of …

Acetaminophen (APAP) overdose-induced acute liver failure is an important clinical problem
in the United States and the current antidote N-acetylcysteine, has a short early therapeutic …

Background and Objectives. Leptadenia hastata is a liana from the family of Asclepiadaceae
used in tropical Africa to treat diabetes mellitus. In this study, we investigated its …

Drug‐induced liver injury (DILI) can lead to acute liver failure, a lethal condition which may
require liver transplantation. Hepatotoxicity associated with nonsteroidal anti‐inflammatory …

We thank Dr. Takahashi and coworkers for their comments on our recently published review
discussing the evidence for various modes of cell death in acetaminophen (APAP)-induced …

Oxidative stress refers to the consequences of exposure to reactive oxygen species. In many
disease conditions, interruption along the mitochondrial electron transport chain (ETC) leads …