Visualization of lipid droplets in living cells and fatty livers of mice based on the fluorescence of π-extended coumarin using fluorescence lifetime imaging microscopy
T Yoshihara, R Maruyama, S Shiozaki… - Analytical …, 2020 - ACS Publications
Lipid droplets (LDs) are closely related to lipid metabolism in living cells and are highly
associated with diverse diseases such as fatty liver, diabetes, and cancer. Herein we …
associated with diverse diseases such as fatty liver, diabetes, and cancer. Herein we …
Hybridization of triphenylamine and salicylaldehyde: a facile strategy to construct aggregation‐induced emission luminogens with excited‐state intramolecular proton …
W Yin, Y Li, N Li, W Yang, H An, J Gao… - Advanced Optical …, 2020 - Wiley Online Library
Aggregation‐induced emission luminogens (AIEgens) with excited‐state intramolecular
proton transfer (ESIPT) process have attracted significant attention in bioimaging …
proton transfer (ESIPT) process have attracted significant attention in bioimaging …
A lipophilic AIEgen for lipid droplet imaging and evaluation of the efficacy of HIF-1 targeting drugs
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates the cellular
response to hypoxia. The upregulation of HIF-1 expression in hypoxic cells can induce the …
response to hypoxia. The upregulation of HIF-1 expression in hypoxic cells can induce the …
A family of push-pull bio-probes for tracking lipid droplets in living cells with the detection of heterogeneity and polarity
L Li, Y Xu, Y Chen, J Zheng, J Zhang, R Li, H Wan… - Analytica Chimica …, 2020 - Elsevier
Lipid droplets (LDs) are multi-functional organelles with the storage of lipid and participating
in a variety of physiological processes, including membrane transport and signal …
in a variety of physiological processes, including membrane transport and signal …
Mitochondrial carnitine palmitoyltransferase 2 is involved in Nε-(carboxymethyl)-lysine-mediated diabetic nephropathy
J Lee, JY Hyon, JY Min, YH Huh, HJ Kim, H Lee… - Pharmacological …, 2020 - Elsevier
Diabetic nephropathy (DN) is the most common cause of end-stage renal disease in the
world. Advanced glycation end products (AGEs) are thought to be involved in the …
world. Advanced glycation end products (AGEs) are thought to be involved in the …
Divergence exists in the subcellular distribution of intramuscular triglyceride in human skeletal muscle dependent on the choice of lipid dye
JA Strauss, DA Shepherd, M Macey… - Histochemistry and Cell …, 2020 - Springer
Despite over 50 years of research, a comprehensive understanding of how intramuscular
triglyceride (IMTG) is stored in skeletal muscle and its contribution as a fuel during exercise …
triglyceride (IMTG) is stored in skeletal muscle and its contribution as a fuel during exercise …
Multidrug resistance protein 4 (MRP4/ABCC4) is overexpressed in clear cell renal cell carcinoma (ccRCC) and is essential to regulate cell proliferation
JPM Colavita, JS Todaro, M de Sousa, M May… - International Journal of …, 2020 - Elsevier
Abstract Kidney cancer accounts for 2.5% of all cancers, with an annual global incidence of
almost 300,000 cases leading to 111,000 deaths. Approximately 85% of kidney tumors are …
almost 300,000 cases leading to 111,000 deaths. Approximately 85% of kidney tumors are …
Pluripotent stem cell-derived hepatocytes phenotypic screening reveals small molecules targeting the cdk2/4-c/ebpα/dgat2 pathway preventing er-stress induced lipid …
M Parafati, SH Bae, RJ Kirby, M Fitzek, P Iyer… - International Journal of …, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) has a large impact on global health. At the onset
of disease, NAFLD is characterized by hepatic steatosis defined by the accumulation of …
of disease, NAFLD is characterized by hepatic steatosis defined by the accumulation of …
Photostable fluorescent probes for 3D imaging and monitoring the metabolism of lipid droplets
In addition to being associated with energy supply, lipid droplets (LDs) play vital roles in
many other important physiological and some pathological processes. Fluorescent probes …
many other important physiological and some pathological processes. Fluorescent probes …
Dibenzothiophene sulfone derivatives as plasma membrane dyes
JT Petroff, S Grady, CK Arnatt… - Photochemistry and …, 2020 - Wiley Online Library
Abstract Dibenzothiophene 5, 5‐dioxide (DBTOO) derivatives have recently been shown to
processes utility as fluorescent cell dyes. In an effort to extend the functionality of DBTOO …
processes utility as fluorescent cell dyes. In an effort to extend the functionality of DBTOO …