Effects of optogenetic stimulation of basal forebrain parvalbumin neurons on Alzheimer's disease pathology
Neuronal activity can modify Alzheimer's disease pathology. Overexcitation of neurons can
facilitate disease progression whereas the induction of cortical gamma oscillations can …
facilitate disease progression whereas the induction of cortical gamma oscillations can …
The role of orthosteric building blocks of bitopic ligands for muscarinic M1 receptors
D Volpato, M Kauk, R Messerer, M Bermudez… - ACS …, 2020 - ACS Publications
The muscarinic M1 acetylcholine receptor is an important drug target for the treatment of
various neurological disorders. Designing M1 receptor-selective drugs has proven …
various neurological disorders. Designing M1 receptor-selective drugs has proven …
Restoring Agonist Function at a Chemogenetically Modified M1 Muscarinic Acetylcholine Receptor
E Khajehali, S Bradley… - ACS Chemical …, 2020 - ACS Publications
Designer receptors exclusively activated by designer drugs (DREADDs) have been
successfully employed to activate signaling pathways associated with specific muscarinic …
successfully employed to activate signaling pathways associated with specific muscarinic …
Di-arginine and FFAT-like motifs retain a subpopulation of PRA1 at ER-mitochondria membrane contact sites
A Abu Irqeba, JM Ogilvie - Plos one, 2020 - journals.plos.org
Prenylated Rab Acceptor 1 (PRA1/Rabac1) is a four-pass transmembrane protein that has
been found to localize to the Golgi and promiscuously associate with a diverse array of Rab …
been found to localize to the Golgi and promiscuously associate with a diverse array of Rab …
Characterization of ligand binding to M1 muscarinic acetylcholine receptor using fluorescence anisotropy method
H Danková - 2020 - dspace.cuni.cz
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and
Toxicology Student: Hana Danková Supervisors: Prof. Ago Rinken, PhD. MSc. Tõnis …
Toxicology Student: Hana Danková Supervisors: Prof. Ago Rinken, PhD. MSc. Tõnis …
Editorial for Advances in G Protein-Coupled Receptor Signal Transduction Special Issue
AB Tobin, SJ Bradley - ACS Pharmacology & Translational …, 2020 - ACS Publications
Edition of ACS Pharmacology and Translational Science we have attempted to capture
some of these advances in a mixture of articles that includes reviews, original research …
some of these advances in a mixture of articles that includes reviews, original research …