Topical formulations for delivery of hedgehog inhibitor compounds and use thereof

MB Brown, CR Stevenson, CRG Evans - US Patent 10,695,344, 2020 - Google Patents
Compositions for topical administration of a hedgehog inhibitor compound are described. In
one embodiment, the hedgehog inhibitor compound is patidegib and the topical composition …

Disubstituted amino acids and methods of preparation and use thereof

K Darlak, N Kawahata, SA Athamneh - US Patent 10,669,230, 2020 - Google Patents
Provided are crystalline a, a-disubstituted amino acids and their crystalline salts containing a
terminal alkene on one of their side chains, as well as optionally crystalline haloge nated …

Methods of use of cyclopamine analogs

AC Castro, MJ Grogan, KJ McGovern… - US Patent …, 2020 - Google Patents
US10821102B2 - Methods of use of cyclopamine analogs - Google Patents
US10821102B2 - Methods of use of cyclopamine analogs - Google Patents Methods of use …

Peptidomimetic macrocycles

V Guerlavais, N Kawahata - US Patent 10,703,780, 2020 - Google Patents
2002/0098580 A1 2002/0132977 Al 2003/0060432 A1 2003/0144331 A1 2003/0176318 Al
2004/0146971 A1 2005/0137137 A1 2005/0227932 Al 2005/0250680 A1 2006/0008848 A1 …

Functionalized linear and cyclic polyolefins

R Tuba, RH Grubbs - US Patent 10,619,003, 2020 - Google Patents
This invention relates to methods and compositions for preparing linear and cyclic
polyolefins. More particularly, the invention relates to methods and compositions for pre …