Improved identification of structural variants (SVs) in cancer can lead to more targeted and
effective treatment options as well as advance our basic understanding of the disease and …

Aberrant gene expression can contribute to brain and nervous system dysfunction that
causes many psychiatric illnesses. Here, we review how transcriptomic approaches have …

Numerous genetic and epigenetic alterations cause functional changes in cell biology
underlying cancer. These hallmark functional changes constitute potentially tissue …

Objective In cartilage, the osteoarthritis (OA) associated single nucleotide polymorphism
(SNP) rs11780978 correlates with differential expression of PLEC, and with differential …

In heterozygous genomes, allele-specific measurements can reveal biologically significant
differences in DNA methylation between homologous alleles associated with local changes …

Adaptation to different pollinators is an important driver of speciation in the angiosperms.
Genetic approaches such as QTL mapping have been successfully used to identify the …

Genome-wide association studies (GWAS) have identified over 100 loci containing single
nucleotide variants (SNVs) that influence the risk of developing multiple sclerosis (MS). Most …

Natural selection on gene expression was originally predicted to result primarily in cis-rather
than trans-regulatory evolution, due to the expectation of reduced pleiotropy. Despite this …

Recent findings indicate that allele-specific expression (ASE) at specific cancer driver gene
loci may be of importance in onset/progression of the disease. Of particular interest are loss …

In diploid organisms, each gene locus is composed of two parental alleles, which would
interact with each other for determining the phenotypic variation. Better understanding of the …