BACKGROUND Historically, cancer has been considered a disease of the cell, caused by
mutations in genes that control proliferation, differentiation, and death. In recent decades …

Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing
evidence has shown that reprogrammed metabolism may play a critical role in the …

Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy typified by a highly
stromal and weakly immunogenic tumor microenvironment that promotes tumor evolution …

Oncogene-induced metabolic reprogramming is a hallmark of pancreatic cancer (PDAC), yet
the metabolic drivers of metastasis are unclear. In PDAC, obesity and excess fatty acids …

Background The prognosis of colon cancer is poor for metastasis, while the mechanism,
especially adipocytes related, is not yet clear. The purpose of this study is to determine the …

Background Obesity is a major risk factor for renal cancer, yet our understanding of its effects
on antitumor immunity and immunotherapy outcomes remains incomplete. Deciphering …

Abstract Interleukin 1 (IL-1) has long been known for its pleiotropic effects on inflammation
that plays a complex, and sometimes contrasting, role in different stages of cancer …

Obesity is a major modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC), yet
how and when obesity contributes to PDAC progression is not well understood. Leveraging …

Pancreatic cancer is one of the leading determinants of global cancer mortality, and its
incidence is predicted to increase, to become in 2030 the second most common cause of …

Cancer progression generates a chronic inflammatory state that dramatically influences
hematopoiesis, originating different subsets of immune cells that can exert pro-or anti-tumor …