Blocking the biological functions of scaffold proteins and aggregated proteins is a
challenging goal. PROTAC proteolysis-targeting chimaera (PROTAC) technology may be …

The formation of insoluble inclusions in the cytosol and nucleus is associated with impaired
protein homeostasis and is a hallmark of several neurodegenerative diseases. Due to the …

Misfolded proteins and insoluble aggregates are continuously produced in the cell and can
result in severe stress that threatens cellular fitness and viability if not managed effectively …

Protein misfolding is a central feature of most neurodegenerative diseases. Molecular
chaperones can modulate the toxicity associated with protein misfolding, but it remains …

Germline mutations in the folliculin (FLCN) tumor suppressor gene are linked to Birt-Hogg-
Dubé (BHD) syndrome, a dominantly inherited genetic disease characterized by …

Protein misfolding is a recurring phenomenon that cells must manage; otherwise misfolded
proteins can aggregate and become toxic should they persist. To counter this burden, cells …

Intracellular protein inclusions are diverse cellular entities with distinct biological properties.
They vary in their protein content, sequestration sites, physiological function, conditions for …

Co-translational degradation via the ubiquitin-proteasome system mediates quality control of
15–25% of nascent proteins, a proportion that is known to increase dramatically as a result …

The heat shock response (HSR) is the cell's primary response to cytosolic misfolded protein.
It is conserved across eukaryotes and is essential for cell survival. How cells detect …

Sarcopenia is a characteristic of ageing where a substantial reduction of muscle tissue,
strength and function are seen (Baumann et al, 2016). Previous reports have suggested that …