The applications of fluorine in drug design continue to expand, facilitated by an improved
understanding of its effects on physicochemical properties and the development of synthetic …

Applications of TEMPO. catalysis for the development of redox‐neutral transformations are
rare. Reported here is the first TEMPO.‐catalyzed, redox‐neutral C− H di‐and …

The biological properties of molecules containing the trifluoromethoxy group have made
these compounds important targets in pharmaceuticals and agrochemicals, yet their …

The development of innovative fluorination strategies is greatly dependent also on the
availability, safety and practicability of available fluorinating reagents. We herein show a …

In the past two decades, the development and application of bench-stable electrophilic
difluoromethylating reagents have attracted considerable attention. Consequently, some …

The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under
continuous-flow conditions is described. Application of continuous-flow microreactor …

Abstract Effects of the trifluoromethoxy substituent on physico-chemical properties of
compounds, such as kinetic solubility, lipophilicity and microsomal clearance, was studied in …

The synthesis of trifluoromethylthiolated ketenimines is herein described. They are easily
synthesized from the corresponding α‐trifluoromethylthiolated oximes upon activation with …

The superacid-promoted electrophilic Csp3–H bond activation of aliphatic amines generates
superelectrophilic species that can be subsequently fluorinated. Demonstrated by low …

The synthetic utility of 2‐trifluoromethyl‐1H‐pyrrole as a pharmaceutically relevant platform
was demonstrated by the preparation of mono‐and bifunctional C‐2 (5)‐or C‐3‐substituted …