Animal and translational models of SARS-CoV-2 infection and COVID-19
COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical
community is in a race to define and develop effective preventions and treatments. The …
community is in a race to define and develop effective preventions and treatments. The …
[HTML][HTML] Why do some asthma patients respond poorly to glucocorticoid therapy?
I Henderson, E Caiazzo, C McSharry, TJ Guzik… - Pharmacological …, 2020 - Elsevier
Glucocorticosteroids are the first-line therapy for controlling airway inflammation in asthma.
They bind intracellular glucocorticoid receptors to trigger increased expression of anti …
They bind intracellular glucocorticoid receptors to trigger increased expression of anti …
Critical role for iron accumulation in the pathogenesis of fibrotic lung disease
Increased iron levels and dysregulated iron homeostasis, or both, occur in several lung
diseases. Here, the effects of iron accumulation on the pathogenesis of pulmonary fibrosis …
diseases. Here, the effects of iron accumulation on the pathogenesis of pulmonary fibrosis …
Role of lung microbiome in innate immune response associated with chronic lung diseases
Respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung
fibrosis, and lung cancer, pose a huge socio-economic burden on society and are one of the …
fibrosis, and lung cancer, pose a huge socio-economic burden on society and are one of the …
Human airway epithelial extracellular vesicle miRNA signature is altered upon asthma development
Background miRNAs are master regulators of signaling pathways critically involved in
asthma and are transferred between cells in extracellular vesicles (EV). We aimed to …
asthma and are transferred between cells in extracellular vesicles (EV). We aimed to …
Hypoxia‐inducible factor and bacterial infections in chronic obstructive pulmonary disease
ABSTRACT COPD is a seriously disabling respiratory condition that inexorably progresses
to disability and mortality. It affects approximately 10% of the population globally with a …
to disability and mortality. It affects approximately 10% of the population globally with a …
A network of sputum microRNAs is associated with neutrophilic airway inflammation in asthma
JL Gomez, A Chen, MP Diaz, N Zirn… - American journal of …, 2020 - atsjournals.org
Rationale: MicroRNAs are potent regulators of biologic systems that are critical to tissue
homeostasis. Individual microRNAs have been identified in airway samples. However, a …
homeostasis. Individual microRNAs have been identified in airway samples. However, a …
Respiratory viral infections in exacerbation of chronic airway inflammatory diseases: novel mechanisms and insights from the upper airway epithelium
KS Tan, RL Lim, J Liu, HH Ong, VJ Tan… - Frontiers in cell and …, 2020 - frontiersin.org
Respiratory virus infection is one of the major sources of exacerbation of chronic airway
inflammatory diseases. These exacerbations are associated with high morbidity and even …
inflammatory diseases. These exacerbations are associated with high morbidity and even …
Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma
Accumulating evidence highlights links between iron regulation and respiratory disease.
Here, we assessed the relationship between iron levels and regulatory responses in clinical …
Here, we assessed the relationship between iron levels and regulatory responses in clinical …
The cell type–specific functions of miR-21 in cardiovascular diseases
B Dai, F Wang, X Nie, H Du, Y Zhao, Z Yin, H Li… - Frontiers in …, 2020 - frontiersin.org
Cardiovascular diseases are one of the prime reasons for disability and death worldwide.
Diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia …
Diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia …