Toll-like receptors and the control of immunity

KA Fitzgerald, JC Kagan - Cell, 2020 - cell.com
The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …

Phytochemicals as anti-inflammatory agents in animal models of prevalent inflammatory diseases

SA Shin, BJ Joo, JS Lee, G Ryu, M Han, WY Kim… - Molecules, 2020 - mdpi.com
Phytochemicals are known to have anti-inflammatory effects in vitro and in vivo, such as in
inflammatory disease model systems. Inflammation is an essential immune response to …

Changes in the global burden of chronic liver diseases from 2012 to 2017: the growing impact of NAFLD

JM Paik, P Golabi, Y Younossi, A Mishra… - Hepatology, 2020 - journals.lww.com
Conclusions Our findings indicate that LINC00665 is involved in the NF‐κB signaling
activation in HCC cells and that the inflammatory LINC00665/PKR/NF‐κB loop plays …

Lactobacillus plantarum KLDS1.0344 and Lactobacillus acidophilus KLDS1.0901 Mixture Prevents Chronic Alcoholic Liver Injury in Mice by Protecting the Intestinal …

H Li, J Shi, L Zhao, J Guan, F Liu… - Journal of Agricultural …, 2020 - ACS Publications
Health and wellbeing are significantly impaired by alcoholic liver disease (ALD), and
although some lactic acid bacteria strains have been shown previously to relieve ALD …

Phillyrin (KD-1) exerts anti-viral and anti-inflammatory activities against novel coronavirus (SARS-CoV-2) and human coronavirus 229E (HCoV-229E) by suppressing …

Q Ma, R Li, W Pan, W Huang, B Liu, Y Xie, Z Wang… - Phytomedicine, 2020 - Elsevier
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
extensively and rapidly spread in the world, causing an outbreak of acute infectious …

Sirtuins and intervertebral disc degeneration: roles in inflammation, oxidative stress, and mitochondrial function

GZ Zhang, YJ Deng, QQ Xie, EH Ren, ZJ Ma, XG He… - Clinica chimica acta, 2020 - Elsevier
Intervertebral disc degeneration (IDD) is one of the main causes of low back pain, which
seriously reduces the quality of life of patients and places a heavy economic burden on their …

Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway

Q Ma, W Pan, R Li, B Liu, C Li, Y Xie, Z Wang… - Pharmacological …, 2020 - Elsevier
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread
worldwide through person-to-person contact, causing a public health emergency of …

Development of a hybrid model for a partially known intracellular signaling pathway through correction term estimation and neural network modeling

D Lee, A Jayaraman, JS Kwon - PLoS Computational Biology, 2020 - journals.plos.org
Developing an accurate first-principle model is an important step in employing systems
biology approaches to analyze an intracellular signaling pathway. However, an accurate first …

p63-related signaling at a glance

ML Fisher, S Balinth, AA Mills - Journal of cell science, 2020 - journals.biologists.com
ABSTRACT p63 (also known as TP63) is a transcription factor of the p53 family, along with
p73. Multiple isoforms of p63 have been discovered and these have diverse functions …

Oleanolic acid enhances tight junctions and ameliorates inflammation in Salmonella typhimurium-induced diarrhea in mice via the TLR4/NF-κB and MAPK pathway

N Dong, C Xue, L Zhang, T Zhang, C Wang, C Bi… - Food & function, 2020 - pubs.rsc.org
Salmonella typhimurium (ST) is a common cause of acute, self-limiting food-borne diarrhea
with severe intestinal inflammation and intestinal barrier damage. Oleanolic acid (OA) …