Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …

Targeting altered tumour metabolism is an emerging therapeutic strategy for cancer
treatment. The metabolic reprogramming that accompanies the development of malignancy …

To sustain their high proliferation rates, most cancer cells rely on glycolytic metabolism, with
production of lactic acid. For many years, lactate was seen as a metabolic waste of glycolytic …

It has been long recognized that cancer cells reprogram their metabolism under hypoxia
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …

Introduction The progression and clinical course of head and neck squamous cell carcinoma
(HNSCC) relies on complex interactions between cancer and stromal cells in the tumor …

Reprogramming of energy metabolism is a key hallmark of cancer. Most cancer cells display
a glycolytic phenotype, with increased glucose consumption and glycolysis rates, and …

Immunotherapy has been recently approved for the treatment of relapsed and metastatic
human papilloma virus (HPV) positive and negative head and neck squamous cell …

Metabolic remodeling is a key phenomenon in the occurrence and development of tumors. It
not only offers materials and energy for the survival and proliferation of tumor cells, but also …

Metabolite exchange between stromal and tumor cells or among tumor cells themselves
accompanies metabolic reprogramming in cancer including pancreatic adenocarcinoma …

Chondrosarcoma is the second most common primary bone malignancy, representing one
fourth of all primary bone sarcomas. It is typically resistant to radiation and chemotherapy …