Bcl‐xL represents a therapeutic target in Philadelphia negative myeloproliferative neoplasms

J Petiti, M Lo Iacono, V Rosso… - Journal of cellular …, 2020 - Wiley Online Library
Myeloproliferative neoplasms are divided into essential thrombocythemia (ET), polycythemia
vera (PV) and primary myelofibrosis (PMF). Although ruxolitinib was proven to be effective in …

[HTML][HTML] c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis

L Li, C Yi, WJ Xia, B Huang, S Chen, J Zhong… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Thrombopoietin (TPO) is a growth factor for the megakaryocytic/platelet lineage. In this
study, we investigated the expression of TPO and its receptor, c-Mpl, in the human central …

The role of Bcl-Xl protein research in veterinary oncology

A Pawlak, M Henklewska - International Journal of Molecular Sciences, 2020 - mdpi.com
Due to their significant impact on human and animal health, cancer diseases are an area of
considerable concern for both human and veterinary medicine. Research on the cancer …

Grass carp (Ctenopharyngodon idella) Bcl-xl: transcriptional regulation and anti-apoptosis analysis

G Qi, N Yu, K Xu, X Xie, Y Mao, X Chen, X Ran… - Fish physiology and …, 2020 - Springer
Abstract Bcl-xl, Bax2, and NF-κB are well-known to be involved in anti-apoptosis response.
Although Bcl-xl has been reported in fish, the NF-κB-mediated regulatory mechanism and …

Compositions and methods for reprogramming adult cells through the stemness of a platelet rich fraction of blood containing platelet-like cells in humans

Y Zhao - US Patent 10,729,730, 2020 - Google Patents
The described invention provides a method of functionally reprogramming adult cells to an
immature cell type that expresses one or more embryonic biomarkers. The reprogramming is …

[PDF][PDF] 巨核球造血におけるアポトーシス関連タンパクの役割

上妻行則, 登尾一平 - 熊本保健科学大学研究誌, 2020 - core.ac.uk
要旨血小板の母細胞である巨核球は, 造血幹細胞から巨核球系特異的サイトカインである
thrombopoietin (TPO) の制御を受け, 分化・成熟し, 分化の最終段階で胞体突起を形成する …