Colorectal cancer (CRC) is a leading cause of death among cancer patients. This
heterogeneous disease is characterized by alterations in multiple molecular pathways …

Although the ever-increasing number of cancer patients pose substantial challenges
worldwide, finding a treatment with the highest response rate and the lowest number of side …

Colorectal cancer (CRC) is still considered as the third most frequent cancer in the world.
Microsatellite instability (MSI), inflammation, and microRNAs have been demonstrated as …

Osteoimmunology was coined about twenty years ago to identify a strict cross talk between
bone niche and immune system both in physiological and pathological activities, including …

Cancer vaccines are usually derived from the patient's tumor cells or the antigens found on
their surface, which may help the immune system to identify and kill these malignant cells …

The development of chemo-resistance against 5-fluorouracil (5-FU) in tumor cells is one of
the main debacles in colorectal cancer (CRC) patients. A recent combination of 5-FU with …

Worldwide, colorectal cancer (CRC) is one of the most common malignant tumors, leading to
immense social and economic burdens. Currently, the main treatments for CRC include …

Over the past decade, immune checkpoint inhibitors (ICI) have proven to be promising
agents in a number of solid tumor malignancies. Pembrolizumab and nivolumab are ICIs …

Background: Colorectal cancer (CRC) accounts for the highest fatality rate among all
malignant tumors. Immunotherapy has shown great promise in management of many …

Colorectal cancer (CRC) is a malignant gastrointestinal cancer that seriously threatens
human health. Its morbidity and mortality are in the forefront of tumors. Chemotherapy and …