Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the
leading causes of death and disability worldwide. As such, new treatments are needed to …

The metabolic requirements of hematopoietic stem cells (HSCs) change with their cell cycle
activity. However, the underlying role of mitochondria remains ill-defined. Here we found …

Maintenance of mitochondrial function and integrity is critical for normal cell survival,
particularly in non-dividing cells with a high-energy demand such as cardiomyocytes. Well …

Maintaining mitochondrial health is emerging as a keystone in aging and associated
diseases. The selective degradation of mitochondria by mitophagy is of particular …

Differential WNT and Notch signaling regulates differentiation of Lgr5+ crypt-based
columnar cells (CBCs) into intestinal cell lineages. Recently we showed that mitochondrial …

Mitochondria are the powerhouse organelles of cells; they participate in ATP generation,
calcium homeostasis, oxidative stress response, and apoptosis. Thus, maintenance of …

Parkinson's disease (PD) that afflicts millions of individuals worldwide is associated with
deposits of aggregate-prone proteins (eg, α-synuclein) and with mitochondrial dysfunction in …

The global burden of neurodegenerative diseases is alarmingly increasing in parallel to the
aging of population. Although the molecular mechanisms leading to neurodegeneration are …

New treatments are needed to protect the myocardium against the detrimental effects of
acute ischaemia/reperfusion (IR) injury following an acute myocardial infarction (AMI), in …