Clinically significant bleeding can occur as a consequence of surgery, trauma, obstetric
complications, anticoagulation, and a wide variety of disorders of hemostasis. As the causes …

Anemia is common in the perioperative period and is associated with poor patient outcomes.
Remarkably, anemia is frequently ignored until hemoglobin levels drop low enough to …

Background Acute blood loss in trauma requires quick identification and action to restore
circulating volume and save the patient. Massive transfusion protocols (MTPs) have become …

Von Willebrand disease (VWD) constitutes the most common inherited human bleeding
disorder. It is associated with a mucocutaneous bleeding phenotype that can significantly …

Background The hemostatic properties of tranexamic acid (TXA) are well described, but the
immunological effects of TXA administration after traumatic injury have not been thoroughly …

Bleeding related to portal hypertension and coagulopathy is a common complication in
patients with cirrhosis. Complications and management of bleeding is a significant source of …

Introduction The conservative management of Chronic subdural hematoma (CSDH) is
controversial. Many drugs have been tried in the conservative management of CSDH …

Importance: Hematoma is the most common complication in rhytidectomy. Tranexamic acid
(TXA) is an antifibrinolytic that may be a useful tool to reduce intraoperative bleeding and …

Embedding physiological markers into treatment algorithms has helped trauma teams
rationalise interventions safely and signifies a departure from the dichotomy of damage …

Background Intraoperative use of tranexamic acid (TXA) has been proven to reduce the
administration of allogenic blood transfusion in total joint arthroplasty (TJA) patients. Data on …