The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

D Bruni, HK Angell, J Galon - Nature Reviews Cancer, 2020 - nature.com
Abstract The international American Joint Committee on Cancer/Union for International
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …

Epidemiology of esophageal cancer: update in global trends, etiology and risk factors

DJ Uhlenhopp, EO Then, T Sunkara… - Clinical journal of …, 2020 - Springer
Esophageal cancer is the eighth most common type of cancer worldwide and constitutes the
sixth leading cause of cancer deaths. It is characterized by its high mortality rate, poor …

The global burden of disease attributable to high body mass index in 195 countries and territories, 1990–2017: An analysis of the Global Burden of Disease Study

H Dai, TA Alsalhe, N Chalghaf, M Riccò… - PLoS …, 2020 - journals.plos.org
Background Obesity represents an urgent problem that needs to be properly addressed,
especially among children. Public and global health policy-and decision-makers need …

Mechanisms of multidrug resistance in cancer chemotherapy

K Bukowski, M Kciuk, R Kontek - International journal of molecular …, 2020 - mdpi.com
Cancer is one of the main causes of death worldwide. Despite the significant development of
methods of cancer healing during the past decades, chemotherapy still remains the main …

DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

RX Huang, PK Zhou - Signal transduction and targeted therapy, 2020 - nature.com
Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

[HTML][HTML] Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis

M Arbyn, E Weiderpass, L Bruni… - The Lancet Global …, 2020 - thelancet.com
Background The knowledge that persistent human papillomavirus (HPV) infection is the
main cause of cervical cancer has resulted in the development of prophylactic vaccines to …

Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies

MA Cupp, M Cariolou, I Tzoulaki, D Aune, E Evangelou… - BMC medicine, 2020 - Springer
Background Although neutrophils have been linked to the progression of cancer, uncertainty
exists around their association with cancer outcomes, depending on the site, outcome and …

New advances in the diagnosis and management of hepatocellular carcinoma

JD Yang, JK Heimbach - Bmj, 2020 - bmj.com
Hepatocellular carcinoma is one of the leading causes of cancer related death in the world.
Biannual surveillance for the disease in patients with cirrhosis and in high risk carriers of …

Tumor-associated macrophages in human breast, colorectal, lung, ovarian and prostate cancers

I Larionova, G Tuguzbaeva, A Ponomaryova… - Frontiers in …, 2020 - frontiersin.org
Tumor-associated macrophages (TAMs) are major innate immune cells that constitute up to
50% of the cell mass of human tumors. TAMs are highly heterogeneous cells that originate …

Depression and anxiety in relation to cancer incidence and mortality: a systematic review and meta-analysis of cohort studies

YH Wang, JQ Li, JF Shi, JY Que, JJ Liu, JM Lappin… - Molecular …, 2020 - nature.com
The link between depression and anxiety status and cancer outcomes has been well-
documented but remains unclear. We comprehensively quantified the association between …