Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of~
20% of commonly used drugs across a broad spectrum of medical disciplines including …

Using pharmacogenetics in guiding drug therapy experiences a steady increase in uptake,
although still leads to discussions as to its clinical use. Psychiatry constitutes a field where …

Importance Genotype-guided prescribing in pediatrics could prevent adverse drug reactions
and improve therapeutic response. Clinical pharmacogenetic implementation guidelines are …

Many genetic variants in drug metabolizing enzymes and transporters have been shown to
be relevant for treating psychiatric disorders. Associations are strong enough to feature on …

Most of the prescribing and dispensing of medicines happens in primary care.
Pharmacogenomics (PGx) is the study and clinical application of the role of genetic variation …

Eliglustat is a first‐line oral therapy for adults with Gaucher disease type 1 (GD1) with
extensive, intermediate, or poor CYP2D6‐metabolizer phenotypes (90% of patients). We …

Realizing the promise of precision medicine in psychiatry is a laudable and beneficial
endeavor, since it should markedly reduce morbidity and mortality and, in effect, alleviate the …

Plasmodium vivax relapse is one of the major causes of sustained global malaria
transmission. Primaquine (PQ) is the only commercial drug available to prevent relapses …

BACKGROUND Depression is an illness characterized by multiple symptoms including
anhedonia, depressed mood, suicidal thoughts, loss of appetite, and psychomotor …

Affecting up to 15% of older adults, late-life depression (LLD) is characterized by the
occurrence of depressive symptoms after the age of 50–65 years and maybe …