Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …

Rheumatoid arthritis is characterized by synovial inflammation and irreversible bone
erosions, both highlighting the immense reciprocal relationship between the immune and …

The treatment of rheumatoid arthritis (RA) is now entering a new era, the era of Janus kinase
(JAK) inhibitors. JAK inhibitors target multiple cytokines including IL-6 and exhibit a …

We aimed to investigate the involvement of macroautophagy/autophagy in autoimmunity in
rheumatoid arthritis (RA) through citrullination of VIM (vimentin) and its interaction with MHC …

Autophagy plays an important role in protecting the host against pathogens. Mycobacterium
tuberculosis can suppress autophagy and then remain dormant and survive within the host …

The purpose of this study was to investigate the effect of knockdown of the yes‐associated
protein (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) on the migration …

Autophagy is considered as an important intracellular mechanism that degrades cytoplasmic
components to furnish additional energy. It has cytoprotective effects through the …

Context Oridonin exhibits various pharmacological and physiological activities, including
antioxidant, antibacterial, anti-inflammatory, pro-apoptotic, anticancer and neurological …

MAP2K1 encodes mitogen-activated protein kinase 1 (MEK1). Mutations in MAP2K1 lead to
continuous activation of MEK/ERK signaling pathway, giving rise to cardio-facio-cutaneous …

Objective Optineurin (OPTN) is an autophagy adaptor/receptor that acts as an intrinsic
negative regulator of osteoclast differentiation. RANKL expressed by rheumatoid arthritis …