Gut microbiota as a trigger for metabolic inflammation in obesity and type 2 diabetes

TPM Scheithauer, E Rampanelli, M Nieuwdorp… - Frontiers in …, 2020 - frontiersin.org
The gut microbiota has been linked to the development of obesity and type 2 diabetes (T2D).
The underlying mechanisms as to how intestinal microbiota may contribute to T2D are only …

Iron metabolism in obesity and metabolic syndrome

Á González-Domínguez, FM Visiedo-García… - International journal of …, 2020 - mdpi.com
Obesity is an excessive adipose tissue accumulation that may have detrimental effects on
health. Particularly, childhood obesity has become one of the main public health problems in …

Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study

CM Petrilli, SA Jones, J Yang, H Rajagopalan… - bmj, 2020 - bmj.com
Objective To describe outcomes of people admitted to hospital with coronavirus disease
2019 (covid-19) in the United States, and the clinical and laboratory characteristics …

Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City

CM Petrilli, SA Jones, J Yang, H Rajagopalan… - MedRxiv, 2020 - medrxiv.org
Background Little is known about factors associated with hospitalization and critical illness
in Covid-19 positive patients. Methods We conducted a cross-sectional analysis of all …

[HTML][HTML] Risk factors for hospitalization and mortality due to COVID-19 in Espírito Santo State, Brazil

RCM Soares, LR Mattos, LM Raposo - The American journal of …, 2020 - ncbi.nlm.nih.gov
Brazil is, at the time of writing, the global epicenter of COVID-19, but information on risk
factors for hospitalization and mortality in the country is still limited. Demographic and …

COVID-19 severity and outcomes in patients with cancer: a matched cohort study

G Brar, LC Pinheiro, M Shusterman, B Swed… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE SARS-CoV-2 (COVID-19) is a systemic infection. Patients with cancer are
immunocompromised and may be vulnerable to COVID-related morbidity and mortality. The …

Adipogenesis: a complex interplay of multiple molecular determinants and pathways

MA Ambele, P Dhanraj, R Giles, MS Pepper - International journal of …, 2020 - mdpi.com
The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

Hypercoagulopathy and adipose tissue exacerbated inflammation may explain higher mortality in COVID-19 patients with obesity

G Pasquarelli-do-Nascimento… - Frontiers in …, 2020 - frontiersin.org
COVID-19, caused by SARS-CoV-2, is characterized by pneumonia, lymphopenia,
exhausted lymphocytes and a cytokine storm. Several reports from around the world have …

Metabolically healthy obesity—heterogeneity in definitions and unconventional factors

I Brandão, MJ Martins, R Monteiro - Metabolites, 2020 - mdpi.com
The concept of heterogeneity among obese individuals in their risk for developing metabolic
dysfunction and associated complications has been recognized for decades. At the origin of …

Elevated adipose tissue associated IL-2 expression in obesity correlates with metabolic inflammation and insulin resistance

S Kochumon, A Al Madhoun, F Al-Rashed, R Thomas… - Scientific reports, 2020 - nature.com
Adipose tissue (AT) associated cytokines are involved in the development of chronic low-
grade inflammation in obese individuals. IL-2, a pleiotropic cytokine, contributes to immune …