Targeting Ras signaling in AML: RALB is a small GTPase with big potential
EJ Pomeroy, CE Eckfeldt - Small GTPases, 2020 - Taylor & Francis
Acute myeloid leukemia (AML) is a devastating malignancy for which novel treatment
approaches are desperately needed. Ras signaling is an attractive therapeutic target for …
approaches are desperately needed. Ras signaling is an attractive therapeutic target for …
Site-specific chemical fatty-acylation for gain-of-function analysis of protein S-palmitoylation in live cells
Y Li, S Wang, Y Chen, M Li, X Dong… - Chemical …, 2020 - pubs.rsc.org
Protein S-palmitoylation, or S-fatty-acylation, regulates many fundamental cellular processes
in eukaryotes. Herein, we present a chemical fatty-acylation approach that involves site …
in eukaryotes. Herein, we present a chemical fatty-acylation approach that involves site …
A Novel α/β Hydrolase Domain Protein Derived From Haemonchus contortus Acts at the Parasite-Host Interface
The α/β-hydrolase domain (ABHD) proteins belonging to α/β-hydrolase (ABH) superfamily
are ubiquitously distributed throughout all the organisms, and their functional roles have …
are ubiquitously distributed throughout all the organisms, and their functional roles have …
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice
NA Zambetti, AJ Firestone… - Blood, The Journal …, 2020 - ashpublications.org
Oncogenic RAS mutations pose substantial challenges for rational drug discovery.
Sequence variations within the hypervariable region of Ras isoforms underlie differential …
Sequence variations within the hypervariable region of Ras isoforms underlie differential …
Inhibition of NRAS signaling in melanoma through direct depalmitoylation using amphiphilic nucleophiles
Activating mutations in the small GTPase NRAS are responsible for driving tumor growth in
several cancers. Unfortunately, the development of NRAS inhibitors has proven difficult due …
several cancers. Unfortunately, the development of NRAS inhibitors has proven difficult due …
ABHD17 enzymes regulate dynamic plasma membrane palmitoylation and N-Ras-dependent cancer growth
JR Remsberg, RM Suciu, NA Zambetti, TW Hanigan… - bioRxiv, 2020 - biorxiv.org
A subset of Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation
cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such …
cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such …
[引用][C] NRAS palmitoylation and oncogenic fitness
LH Castilla - Blood, The Journal of the American Society of …, 2020 - ashpublications.org
In this issue of Blood, Zambetti et al validate that palmitoylation of mutant NRAS is essential
for its oncogenic function by using a genetic mouse model. Their study highlights that the …
for its oncogenic function by using a genetic mouse model. Their study highlights that the …