Immunity, hypoxia, and metabolism–the Ménage à Trois of cancer: implications for immunotherapy

C Riera-Domingo, A Audigé, S Granja… - Physiological …, 2020 - journals.physiology.org
It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …

Crucial players in glycolysis: cancer progress

Z Abbaszadeh, S Çeşmeli, ÇB Avcı - Gene, 2020 - Elsevier
Cancer is the second most important cause of death and new therapy modalities continue to
be developed and evolved. Cancer cells' metabolism is far different from the normal, healthy …

[HTML][HTML] Metabolic plasticity in chemotherapy resistance

MA Desbats, I Giacomini, T Prayer-Galetti… - Frontiers in …, 2020 - frontiersin.org
Resistance of cancer cells to chemotherapy is the first cause of cancer-associated death.
Thus, new strategies to deal with the evasion of drug response and to improve clinical …

[HTML][HTML] Lactic acidosis interferes with toxicity of perifosine to colorectal cancer spheroids: multimodal imaging analysis

B Pavlatovská, M Machálková, P Brisudová… - Frontiers in …, 2020 - frontiersin.org
Colorectal cancer (CRC) is a disease with constantly increasing incidence and high
mortality. The treatment efficacy could be curtailed by drug resistance resulting from poor …

Pretreatment serum neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios: Two tumor-related systemic inflammatory markers in patients with thymic epithelial …

L Wang, M Ruan, H Yan, B Lei, X Sun, C Chang, L Liu… - Cytokine, 2020 - Elsevier
Objectives To understand underlying changes in pretreatment serum inflammatory markers
associated with thymic epithelial tumors (TETs) development. Methods A retrospective …

Autophagy driven extracellular vesicles in the leukaemic microenvironment

RH Horton, T Wileman… - Current Cancer Drug …, 2020 - ingentaconnect.com
The leukaemias are a heterogeneous group of blood cancers, which together, caused
310,000 deaths in 2016. Despite significant research into their biology and therapeutics …

[HTML][HTML] Exploiting Cancer's tactics to make cancer a manageable chronic disease

K Afrasiabi, ME Linskey, YH Zhou - Cancers, 2020 - mdpi.com
The history of modern oncology started around eighty years ago with the introduction of
cytotoxic agents such as nitrogen mustard into the clinic, followed by multi-agent …

Recent advances in drug development targeting cancer metabolism

N Sugandha, L Mittal, A Awasthi, S Asthana - Cancer Cell Metabolism: A …, 2020 - Springer
Cancer cell proliferation and their adaptation to tough environments depend critically on
metabolic pathways. The pathological, phenotypic, and structural level understanding of …