The exon junction complex (EJC) is an abundant messenger ribonucleoprotein (mRNP)
component that is assembled during splicing and binds to mRNAs upstream of exon-exon …

Nonsense mutations often result from single nucleotide substitutions that change a sense
codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) …

To gain insight into the mechanistic link between translation termination and nonsense-
mediated mRNA decay (NMD), we depleted the ribosome recycling factor ABCE1 in human …

The presence of premature termination codons (PTCs) in transcripts is dangerous for the cell
as they encode potentially deleterious truncated proteins that can act with dominant …

RNA-binding protein with serine-rich domain 1 (RNPS1) is essential for modulating mRNA
metabolism, but its role in ischemic stroke is unknown. In this study, we found that RNPS1 …

Nonsense-mediated mRNA decay (NMD) targets mRNAs that contain a premature
termination codon (PTC) for degradation, preventing their translation. By altering the …

Nonsense-mediated mRNA decay (NMD) is a translation-dependent mRNA surveillance
pathway that eliminates transcripts with premature termination codons. Several studies have …

Microsatellite-unstable (MSI) colorectal cancer is characterized by the accumulation of
somatic insertion/deletion (InDel) mutations potentially generating tumor-specific …

Abstract The Exon Junction Complex, or EJC, is a group of proteins deposited on mRNA
upstream of exon-exon junctions during splicing, and which stays with the mRNA up until …

The presence of premature termination codons (PTCs) in transcripts is dangerous for the cell
as they encode potentially deleterious truncated proteins that can act with dominant …