Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …

Brain plasticity is dynamically regulated across the life span, peaking during windows of
early life. Typically assessed in the physiological range of milliseconds (real time), these …

Parkinson's disease (PD) pathogenesis may involve the epigenetic control of enhancers that
modify neuronal functions. Here, we comprehensively examine DNA methylation at …

Epigenetic mechanisms govern the transcription of the genome. Research with model
systems reveals that environmental conditions can directly influence epigenetic mechanisms …

Memories are encoded by memory traces or engrams, represented within subsets of
neurons that are synchronously activated during learning. However, the molecular …

Cognitive decline is a hallmark of the aging nervous system, characterized by increasing
memory loss and a deterioration of mental capacity, which in turn creates a favorable context …

Neural development requires the orchestration of dynamic changes in gene expression to
regulate cell fate decisions. This regulation is heavily influenced by epigenetics, heritable …

The neural cell adhesion molecule 1 (NCAM-1) has been implicated in several brain-related
biological processes, including neuronal migration, axonal branching, fasciculation, and …

Abstract TET enzymes oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine
(5hmC), a process thought to be intermediary in an active DNA demethylation mechanism …

The balance of excitation and inhibition is essential for cortical information processing,
relying on the tight orchestration of the underlying subcellular processes. Dynamic …