Enhanced closed eye neutrophil degranulation in dry eye disease

CK Postnikoff, K Held, V Viswanath, KK Nichols - The ocular surface, 2020 - Elsevier
Purpose Closed eye neutrophils have demonstrated increased prevalence in dry eye
disease, but the phenotype and extent of activation of these cells has yet to be described …

Lipidomic analysis of epithelial corneal cells following hyperosmolarity and benzalkonium chloride exposure: New insights in dry eye disease

R Magny, K Kessal, A Regazzetti, AB Yedder… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Dry eye disease (DED) is a multifactorial chronic inflammatory disease of the ocular surface
characterized by tear film instability, hyperosmolarity, cell damage and inflammation …

[HTML][HTML] Exposure to traffic-related particulate matter 2.5 triggers Th2-dominant ocular immune response in a murine model

HS Lee, S Han, JW Seo, KJ Jeon - International Journal of Environmental …, 2020 - mdpi.com
Ambient particulate matter (PM), a major component of air pollution, aggravates ocular
discomfort and inflammation, similarly to dry eye disease (DED) or allergies. However, the …

[HTML][HTML] Cluster Analysis of Dry Eye Disease Models Based on Immune Cell Parameters–New Insight Into Therapeutic Perspective

CT Lio, SK Dhanda, T Bose - Frontiers in Immunology, 2020 - frontiersin.org
Dry eye disease (DED) can be represented as a display of disease in the mucosal part of the
eye. It is quite distinct from the retinal side of the eye which connects with the neurons and …

Polymorphic form of N-{6-(hydroxypropan-2-yl)-2-[2-(methylsulphonyl) ethyl]-2H-indazol-5-yl}-6-(trifluoromethyl) pyridine-2-carboxamide

T Thaler, J Platzek, N Guimond - US Patent 10,759,758, 2020 - Google Patents
Damasio (1996).“Alzheimer's Disease and Related Dementias," Cecil Textbook of Medicine,
20th Edition, vol. 2, pp. 1992-1996. Gura, T.(1997)." Systems for identifying new drugs are …

[HTML][HTML] Resistance of the murine cornea to bacterial colonization during experimental dry eye

SJ Wan, S Ma, DJ Evans, SMJ Fleiszig - PloS one, 2020 - journals.plos.org
The healthy cornea is remarkably resistant to infection, quickly clearing deliberately
inoculated bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus …

Synthesis of indazoles

T Thaler, J Platzek, N Guimond - US Patent 10,633,365, 2020 - Google Patents
US10633365B2 - Synthesis of indazoles - Google Patents US10633365B2 - Synthesis of
indazoles - Google Patents Synthesis of indazoles Download PDF Info Publication number …

Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted …

U Bothe, H Siebeneicher, N Schmidt… - US Patent …, 2020 - Google Patents
A61K 31/4439 (2006.01) A61P 19/02(2006.01) CO7F 7/18(2006.01) C07D 405/14
(2006.01)(52) US Ci. CPC C07D 401/12 (2013.01); A61K 31/4439 (2013.01); A61P 19/02 …

Human Organ-On-Chips For The Study Of Biomechanical Forces In Health And Disease

J Seo - 2020 - search.proquest.com
The dynamically changing biomechanical environment in human organs plays a profound
role in various cellular functions such as proliferation, three-dimensional (3D) tissue …