Cystic fibrosis (CF) remains the most common life-shortening hereditary disease in white
populations, with high morbidity and mortality related to chronic airway mucus obstruction …

Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and
physiology of tubular organs. These technologies can mimic human pathophysiology and …

Recently, various types of cultured cells have been used to research the mechanisms of
transport and metabolism of drugs. Although many studies using cultured cell systems have …

Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the CF
transmembrane conductance regulator (CFTR) gene, encoding an anion channel that …

Cystic fibrosis (CF) lung disease is characterized by an inflammatory response that can lead
to terminal respiratory failure. The cystic fibrosis transmembrane conductance regulator …

Background Chronic pulmonary infection is a hallmark of lung disease in cystic fibrosis.
Infections dominated by organisms of the Burkholderia cepacia complex, a group of at least …

Rationale: In cystic fibrosis the major cause of morbidity and mortality is lung disease
characterized by inflammation and infection. The influence of sphingolipid metabolism is …

Bacterial toxins play a key role in the pathogenesis of lung disease. Based on their structural
and functional properties, they employ various strategies to modulate lung barrier function …

Cystic fibrosis (CF) is a genetic disease characterized by the lack of cystic fibrosis
transmembrane conductance regulator (CFTR) protein expressed in epithelial cells. The …

Primary human bronchial epithelial cell (HBEC) cultures are a useful model for studies of
lung health and major airway diseases. However, mechanistic studies have been limited by …