Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …

The misfolding of proteins is now recognized to be the origin of a large number of medical
disorders. One particularly important group of such disorders is associated with the …

Oligomeric species populated during the aggregation of the Aβ42 peptide have been
identified as potent cytotoxins linked to Alzheimer's disease, but the fundamental molecular …

The amyloid cascade hypothesis, according to which the self-assembly of amyloid-β peptide
(Aβ) is a causative process in Alzheimer's disease, has driven many therapeutic efforts for …

Alzheimer's disease (AD) is one of the most common age-associated brain diseases and is
induced by the accumulation of amyloid beta (Aβ) and oxidative stress. Many studies have …

Disordered proteins are challenging therapeutic targets, and no drug is currently in clinical
use that modifies the properties of their monomeric states. Here, we identify a small …

Protein misfolding into amyloid fibrils is linked to more than 40 as yet incurable cell‐and
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and type 2 …

α-Synuclein amyloid aggregation is a defining molecular feature of Parkinson's disease,
Lewy body dementia, and multiple system atrophy, but can also be found in other …

The onset and progression of numerous protein misfolding diseases are associated with the
presence of oligomers formed during the aberrant aggregation of several different proteins …

The formation of amyloid deposits in human tissues is a defining feature of more than 50
medical disorders, including Alzheimer's disease. Strong genetic and histological evidence …