Sensorineural hearing loss is the most common sensory deficit in humans. Despite the
global scale of the problem, only limited treatment options are available today. The …

Cochlear hair cells (HCs) are the mechanoreceptors of the auditory system, and because
these cells cannot be spontaneously regenerated in adult mammals, hearing loss due to HC …

Mechano-sensory hair cells within the inner ear cochlea are essential for the detection of
sound. In mammals, cochlear hair cells are only produced during development and their …

Foxg1 plays important roles in regeneration of hair cell (HC) in the cochlea of neonatal
mouse. Here, we used Sox9-CreER to knock down Foxg1 in supporting cells (SCs) in the …

Sensorineural hearing loss is a common disability often caused by the loss of sensory hair
cells in the cochlea. Hair cell (HCs) regeneration has long been the main target for the …

Loss of inner ear hair cells leads to incurable balance and hearing disorders because these
sensory cells do not effectively regenerate in humans. A potential starting point for therapy …

Cellular mechanotransduction plays an essential role in the development and differentiation
of many cell types, but if and how mechanical cues from the extracellular matrix (ECM) …

Nearly 460 million individuals are affected by sensorineural hearing loss (SNHL), one of the
most common human sensory disorders. In mammals, hearing loss is permanent due to the …

Sensory hair cell losses underlie the vast majority of permanent hearing and balance deficits
in humans, but many nonmammalian vertebrates can fully recover from hearing impairments …

The hair cells that reside in the cochlear sensory epithelium are the fundamental sensory
structures responsible for understanding the mechanical sound waves evoked in the …