Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …

Macrophages are crucial members of the innate immune response and important regulators.
The differentiation and activation of macrophages require the timely regulation of gene …

Cell differentiation and function are regulated across multiple layers of gene regulation,
including modulation of gene expression by changes in chromatin accessibility. However …

Despite the prevalence and clinical importance of influenza, its long-term effect on lung
immunity is unclear. Here we describe that following viral clearance and clinical recovery, at …

Monocytes and macrophages provide defence against pathogens and danger signals.
These cells respond to stimulation in a fast and stimulus-specific manner by utilizing …

Cell-type-and condition-specific profiles of gene expression require coordination between
protein-coding gene promoters and cis-regulatory sequences called enhancers. Enhancers …

Senescent cells affect many physiological and pathophysiological processes. While select
genetic and epigenetic elements for senescence induction have been identified, the …

Trained immunity confers a sustained augmented response of innate immune cells to a
secondary challenge, via a process dependent on metabolic and transcriptional …

Innate immune responses rely on rapid and precise gene regulation mediated by
accessibility of regulatory regions to transcription factors (TFs). In natural killer (NK) cells and …

Frailty is a syndrome characterized by the decline in the physiologic reserve and function of
several systems, leading to increased vulnerability and adverse health outcomes. While …