Next-generation sequencing (NGS) allows sequencing of a high number of nucleotides in a
short time frame at an affordable cost. While this technology has been widely implemented …

A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to developing more efficient cancer detection methods and …

Various species of the intestinal microbiota have been associated with the development of
colorectal cancer,, but it has not been demonstrated that bacteria have a direct role in the …

Extrachromosomal DNA (ecDNA) amplification promotes intratumoral genetic heterogeneity
and accelerated tumor evolution,–; however, its frequency and clinical impact are unclear …

Abstract The Zero Childhood Cancer Program is a precision medicine program to benefit
children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline …

Pancreatic ductal adenocarcinoma (PDA) is among the most immune-resistant tumor types.
Its unique genomic landscape shaped by oncogenic drivers promotes immune suppression …

Homologous recombination deficiency (HRD) results in impaired double strand break repair
and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar …

Chromosomal instability in cancer consists of dynamic changes to the number and structure
of chromosomes,. The resulting diversity in somatic copy number alterations (SCNAs) may …

We integrate the genomics, proteomics, and phosphoproteomics of 480 clinical tissues from
146 patients in a Chinese colorectal cancer (CRC) cohort, among which 70 had metastatic …

Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of
which cannot be easily classified into simple (eg, deletion) or complex (eg, chromothripsis) …