Perivascular adipose tissue regulates vascular function by targeting vascular smooth muscle cells

L Chang, MT Garcia-Barrio, YE Chen - … , thrombosis, and vascular …, 2020 - Am Heart Assoc
Adipose tissues are present at multiple locations in the body. Most blood vessels are
surrounded with adipose tissue which is referred to as perivascular adipose tissue (PVAT) …

Visceral obesity and its shared role in cancer and cardiovascular disease: A scoping review of the pathophysiology and pharmacological treatments

E Aparecida Silveira, G Vaseghi… - International journal of …, 2020 - mdpi.com
The association between obesity, cancer and cardiovascular disease (CVD) has been
demonstrated in animal and epidemiological studies. However, the specific role of visceral …

Visfatin/eNampt induces endothelial dysfunction in vivo: a role for Toll-Like Receptor 4 and NLRP3 inflammasome

T Romacho, I Valencia, M Ramos-González… - Scientific reports, 2020 - nature.com
Abstract Visfatin/extracellular-nicotinamide-phosphoribosyltranferase-(eNampt) is a
multifaceted adipokine enhanced in type-2-diabetes and obesity. Visfatin/eNampt cause in …

Targeting perivascular and epicardial adipose tissue inflammation: therapeutic opportunities for cardiovascular disease

R Rafeh, A Viveiros, GY Oudit, AF El-Yazbi - Clinical Science, 2020 - portlandpress.com
Major shifts in human lifestyle and dietary habits toward sedentary behavior and refined food
intake triggered steep increase in the incidence of metabolic disorders including obesity and …

Potential role of perivascular adipose tissue in modulating atherosclerosis

S Ahmadieh, HW Kim, NL Weintraub - Clinical Science, 2020 - portlandpress.com
Perivascular adipose tissue (PVAT) directly juxtaposes the vascular adventitia and contains
a distinct mixture of mature adipocytes, preadipocytes, stem cells, and inflammatory cells …

Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide

T Horimatsu, AL Blomkalns, M Ogbi… - Cardiovascular …, 2020 - academic.oup.com
Aims Chronic adventitial and medial infiltration of immune cells play an important role in the
pathogenesis of abdominal aortic aneurysms (AAAs). Nicotinic acid (niacin) was shown to …

Perivascular adipose tissue as a target for antioxidant therapy for cardiovascular complications

AWC Man, Y Zhou, N Xia, H Li - Antioxidants, 2020 - mdpi.com
Perivascular adipose tissue (PVAT) is the connective tissue surrounding most of the
systemic blood vessels. PVAT is now recognized as an important endocrine tissue that …

[HTML][HTML] NAD+ metabolism as an emerging therapeutic target for cardiovascular diseases associated with sudden cardiac death

W Xu, L Li, L Zhang - Frontiers in physiology, 2020 - frontiersin.org
In addition to its central role in mediating oxidation reduction in fuel metabolism and
bioenergetics, nicotinamide adenine dinucleotide (NAD+) has emerged as a vital co …

[HTML][HTML] Bone marrow adipocytes, adipocytokines, and breast cancer cells: novel implications in bone metastasis of breast cancer

C Liu, Q Zhao, X Yu - Frontiers in oncology, 2020 - frontiersin.org
Accumulating discoveries highlight the importance of interaction between marrow stromal
cells and cancer cells for bone metastasis. Bone is the most common metastatic site of …

Can adipokine visfatin be a novel marker of pregnancy‐related disorders in women with obesity?

A Wnuk, A Stangret, M Wątroba, AE Płatek… - Obesity …, 2020 - Wiley Online Library
Overweight and obesity have become a dangerous disease requiring multiple interventions,
treatment and preventions. In women of reproductive age, obesity is one of the most …