A tumor suppressor DLC1: The functions and signal pathways

Y Zhang, G Li - Journal of Cellular Physiology, 2020 - Wiley Online Library
Deleted in liver cancer‐1 (DLC1), a potential tumor suppressor, acts as a GTPase‐activating
protein for Rho family members. In many human cancers, the DLC1 expression is frequently …

DLC1 SAM domain-binding peptides inhibit cancer cell growth and migration by inactivating RhoA

R Joshi, L Qin, X Cao, S Zhong, C Voss, W Min… - Journal of Biological …, 2020 - ASBMB
Deleted-in-liver cancer 1 (DLC1) exerts its tumor suppressive function mainly through the
Rho-GTPase–activating protein (RhoGAP) domain. When activated, the domain promotes …

Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative activation of MMP9 expression in melanoma

X Yang, F Hu, JA Liu, S Yu, MPL Cheung, X Liu, IOL Ng… - Oncogene, 2020 - nature.com
A Rho GTPase-activating protein (RhoGAP), deleted in liver cancer 1 (DLC1), is known to
function as a tumor suppressor in various cancer types; however, whether DLC1 is a tumor …