From design to applications of stimuli-responsive hydrogel strain sensors

D Zhang, B Ren, Y Zhang, L Xu, Q Huang… - Journal of materials …, 2020 - pubs.rsc.org
Stimuli-responsive hydrogel strain sensors that synergize the advantages of both soft-wet
hydrogels and smart functional materials have attracted rapidly increasing interest for …

Rationally designed multivalent aptamers targeting cell surface for biomedical applications

M Lin, J Zhang, H Wan, C Yan, F Xia - ACS Applied Materials & …, 2020 - ACS Publications
Specific interactions between ligands and receptors on cell surface play an important role in
the cell biological process. Nucleic acid aptamers as commonly used ligands enable …

Fluidic multivalent membrane nanointerface enables synergetic enrichment of circulating tumor cells with high efficiency and viability

L Wu, H Ding, X Qu, X Shi, J Yang… - Journal of the …, 2020 - ACS Publications
The ubiquitous biomembrane interface, with its dynamic lateral fluidity, allows membrane-
bound components to rearrange and localize for high-affinity multivalent ligand–receptor …

Programming cell–cell communications with engineered cell origami clusters

Z Ge, J Liu, L Guo, G Yao, Q Li, L Wang… - Journal of the …, 2020 - ACS Publications
Cells existing in the form of clusters often exhibit distinct physiological functions from their
monodispersed forms, which have a close association with tissue and organ development …

Bioinspired DNA nanointerface with anisotropic aptamers for accurate capture of circulating tumor cells

W Qin, L Chen, Z Wang, Q Li, C Fan, M Wu… - Advanced …, 2020 - Wiley Online Library
The capture and analysis of circulating tumor cells (CTCs) have provided a non‐invasive
entry for cancer diagnosis and disease monitoring. Despite recent development in affinity …

Ultrafast DNA sensors with DNA framework-bridged hybridization reactions

F Li, X Mao, F Li, M Li, J Shen, Z Ge… - Journal of the …, 2020 - ACS Publications
Intracellular DNA-based hybridization reactions generally occur under tension rather than in
free states, which are spatiotemporally controlled in physiological conditions. However, how …

DNA Framework‐Based Topological Cell Sorters

F Yin, M Li, X Mao, F Li, X Xiang, Q Li… - Angewandte …, 2020 - Wiley Online Library
Molecular recognition in cell biological process is characterized with specific locks‐and‐
keys interactions between ligands and receptors, which are ubiquitously distributed on cell …

Aptamer-based liquid biopsy

L Wu, Y Wang, L Zhu, Y Liu, T Wang, D Liu… - ACS applied bio …, 2020 - ACS Publications
Liquid biopsy allows noninvasive and real-time analysis of tumor-derived circulating targets
in body fluids, holding great value for cancer diagnosis, prognosis, personalized therapy, as …

Extracellular ion-responsive logic sensors utilizing DNA dimeric nanoassemblies on cell surface and application to boosting AS1411 internalization

P Peng, Q Wang, Y Du, H Wang, L Shi, T Li - Analytical Chemistry, 2020 - ACS Publications
High levels of extracellular H+ and K+ are unique features of the tumor microenvironment
and have shown great promise for use in cancer-targeted drug delivery. Here, we design H+ …

Designer, programmable 3D DNA nanodevices to probe biological systems

A Rajwar, S Kharbanda… - ACS Applied Bio …, 2020 - ACS Publications
DNA nanotechnology is a unique field that provides simple yet robust design techniques for
self-assembling nanoarchitectures with extremely high potential for biomedical applications …