Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

M Mehta, DS Dhanjal, KR Paudel, B Singh… - …, 2020 - Springer
Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are
amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases …

Prospects for RNAi therapy of COVID-19

H Uludağ, K Parent, HM Aliabadi… - … in Bioengineering and …, 2020 - frontiersin.org
COVID-19 caused by the SARS-CoV-2 virus is a fast emerging disease with deadly
consequences. The pulmonary system and lungs in particular are most prone to damage …

Antiproliferative effects of boswellic acid-loaded chitosan nanoparticles on human lung cancer cell line A549

N Solanki, M Mehta, DK Chellappan… - Future medicinal …, 2020 - Taylor & Francis
Aim: In the present study boswellic acids-loaded chitosan nanoparticles were synthesized
using ionic gelation technique. The influence of independent variables were studied and …

Perspectives and advancements in the design of nanomaterials for targeted cancer theranostics

YY Tan, PK Yap, GLX Lim, M Mehta, Y Chan… - Chemico-biological …, 2020 - Elsevier
Cancer continues to be one of the most challenging diseases to be treated and is one of the
leading causes of deaths around the globe. Cancers account for 13% of all deaths each …

Solid lipid nanoparticles containing anti-tubercular drugs attenuate the Mycobacterium marinum infection

S Khatak, M Mehta, R Awasthi, KR Paudel, SK Singh… - Tuberculosis, 2020 - Elsevier
The present study aimed to formulate anti-tubercular drugs (Rifampicin, Isoniazid and
Pyrazinamide) loaded solid lipid nanoparticles (ATDs-SLNs) using microemulsion technique …

Molecular mechanisms of action of naringenin in chronic airway diseases

LH Chin, CM Hon, DK Chellappan, J Chellian… - European journal of …, 2020 - Elsevier
Chronic airway inflammatory diseases are characterized by persistent proinflammatory
responses in the respiratory tract. Although, several treatment strategies are currently …

Therapeutic RNA strategies for chronic obstructive pulmonary disease

D Mei, WSD Tan, Y Tay, A Mukhopadhyay… - Trends in …, 2020 - cell.com
Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation with
persistent respiratory symptoms. Current therapeutics for COPD are largely borrowed from …

Protective role of poly (lactic‐co‐glycolic) acid nanoparticle loaded with resveratrol against isoproterenol‐induced myocardial infarction

L Sun, Y Hu, A Mishra, N Sreeharsha, JB Moktan… - Biofactors, 2020 - Wiley Online Library
Our study is aimed at evaluating the effects of pretreatment with Poly (lactic‐co‐glycolic) acid
nanoparticle loaded with resveratrol (RSV PLGA NPs) compared to conventional resveratrol …

RNAi therapeutics: an antiviral strategy for human infections

AD Kelleher, C Cortez-Jugo, F Cavalieri, Y Qu… - Current Opinion in …, 2020 - Elsevier
Highlights•RNAi is a promising antiviral development strategy.•Pathways include classic
RNAi (mRNA target) and novel RNAi (promoter target).•Most RNAi therapeutics act via …

Advanced drug delivery systems can assist in managing influenza virus infection: A hypothesis

Y Chan, SW Ng, M Mehta, K Anand, SK Singh… - Medical hypotheses, 2020 - Elsevier
Outbreaks of influenza infections in the past have severely impacted global health and
socioeconomic growth. Antivirals and vaccines are remarkable medical innovations that …