Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …

Medulloblastoma (MB) is the most common CNS embryonal tumor. While the overall cure
rate is around 70%, patients with high‐risk disease continue to have poor outcome and …

Medulloblastoma (MB) is the most common malignant brain tumor in children and among
the subtypes, Group 3 MB has the worst outcome. Here, we perform an in vivo, patient …

De novo germline mutations in the RNA helicase DDX3X account for 1%–3% of
unexplained intellectual disability (ID) cases in females and are associated with autism …

Epigenetic processes are essential for normal development and the maintenance of tissue-
specific gene expression in mammals. Changes in gene expression and malignant cellular …

Central nervous system (CNS) tumors are the most common solid tumor in pediatrics,
accounting for approximately 25% of all childhood cancers, and the second most common …

Medulloblastoma (MB) is the most common malignant childhood tumor of the brain.
Multimodal treatment consisting of surgery, radiation therapy, and chemotherapy reduced …

Medulloblastoma (MB) represents a spectrum of biologically and clinically distinct entities.
Initially described histopathologically as a small, round blue cell tumor arising in the …

Abstract Li–Fraumeni syndrome (LFS), caused by the germline mutations in the TP53 gene,
leads to significant lifetime risk to cancer in the central nervous system. Recognition of LFS …

PURPOSE The identification of a heritable tumor predisposition often leads to changes in
management and increased surveillance of individuals who are at risk; however, for many …