Epidemiology of the classical myeloproliferative neoplasms: the four corners of an expansive and complex map

RM Shallis, R Wang, A Davidoff, X Ma, NA Podoltsev… - Blood reviews, 2020 - Elsevier
The classical myeloproliferative neoplasms (MPNs), specifically chronic myeloid leukemia
(CML), polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis …

MPN: the molecular drivers of disease initiation, progression and transformation and their effect on treatment

J Grabek, J Straube, M Bywater, SW Lane - Cells, 2020 - mdpi.com
Myeloproliferative neoplasms (MPNs) constitute a group of disorders identified by an
overproduction of cells derived from myeloid lineage. The majority of MPNs have an …

The essential thrombocythemia in 2020: what we know and where we still have to dig deep

V Accurso, M Santoro, S Mancuso… - Clinical Medicine …, 2020 - journals.sagepub.com
The Essential Thrombocythemia is a Chronic Philadelphia-negative Myeloproliferative
Neoplasm characterized by a survival curve that is only slightly worse than that of age-and …

Cytokine profiling in myeloproliferative neoplasms: overview on phenotype correlation, outcome prediction, and role of genetic variants

E Masselli, G Pozzi, G Gobbi, S Merighi, S Gessi… - Cells, 2020 - mdpi.com
Among hematologic malignancies, the classic Philadelphia-negative chronic
myeloproliferative neoplasms (MPNs) are considered a model of inflammation-related …

Next generation sequencing in MPNs. Lessons from the past and prospects for use as predictors of prognosis and treatment responses

V Skov - Cancers, 2020 - mdpi.com
The myeloproliferative neoplasms (MPNs) are acquired hematological stem cell neoplasms
characterized by driver mutations in JAK2, CALR, or MPL. Additive mutations may appear in …

Thrombosis among 1537 patients with JAK2V617F‐mutated myeloproliferative neoplasms: Risk factors and development of a predictive model

Y Zhang, Y Zhou, Y Wang, G Teng, D Li… - Cancer …, 2020 - Wiley Online Library
To explore the risk factors of thrombosis in patients with JAK2V617F‐mutated
myeloproliferative neoplasms (MPNs), a cohort of 1537 Chinese patients with JAK2V617F …

The myelodepletive phenotype in myelofibrosis: clinical relevance and therapeutic implication

BK Marcellino, S Verstovsek, J Mascarenhas - … Lymphoma Myeloma and …, 2020 - Elsevier
Myelofibrosis (MF) is a BCR-ABL1− myeloproliferative neoplasm that arises from
hematopoietic stem and progenitor cells frequently harboring a somatic driver mutation in 1 …

Clonal hematopoiesis and mutations of myeloproliferative neoplasms

L Kjær - Cancers, 2020 - mdpi.com
Myeloproliferative neoplasms (MPNs) are associated with the fewest number of mutations
among known cancers. The mutations propelling these malignancies are phenotypic drivers …

Mutant calreticulin in the myeloproliferative neoplasms

D Prins, CG Arias, T Klampfl, J Grinfeld, AR Green - Hemasphere, 2020 - journals.lww.com
Mutations in the gene for calreticulin (CALR) were identified in the myeloproliferative
neoplasms (MPNs) essential thrombocythaemia (ET) and primary myelofibrosis (MF) in …

Myeloproliferative neoplasms in children, adolescents, and young adults

N Kucine - Current hematologic malignancy reports, 2020 - Springer
Abstract Purpose of Review Myeloproliferative neoplasms are traditionally seen in older
adults, making them poorly understood in younger patients. Clinical presentation, genetic …