[HTML][HTML] International recommendations on the diagnosis and treatment of acquired hemophilia A

A Tiede, P Collins, P Knoebl, J Teitel, C Kessler… - …, 2020 - ncbi.nlm.nih.gov
Acquired hemophilia A (AHA), a rare bleeding disorder caused by neutralizing
autoantibodies against coagulation factor VIII (FVIII), occurs in both men and women without …

The first case of acquired hemophilia A associated with SARS‐CoV‐2 infection

M Franchini, C Glingani, G De Donno… - American Journal of …, 2020 - ncbi.nlm.nih.gov
To the Editor: Acquired hemophilia A (AHA) is a rare bleeding disorder caused by circulating
autoantibodies directed against clotting factor VIII (FVIII). 1, 2 It involves more frequently …

[HTML][HTML] Acquired haemophilia A: an intriguing disease

MG Mazzucconi, E Baldacci, A Ferretti… - … Journal of Hematology …, 2020 - ncbi.nlm.nih.gov
Acquired Haemophilia A is a rare acquired bleeding disorder caused by Factor VIII
autoantibodies, which neutralise FVIII activity. These inhibitors differ from alloantibodies …

Bleeding and response to hemostatic therapy in acquired hemophilia A: results from the GTH-AH 01/2010 study

K Holstein, X Liu, A Smith, P Knöbl… - Blood, The Journal …, 2020 - ashpublications.org
Acquired hemophilia A (AHA) is due to autoantibodies against coagulation factor VIII (FVIII)
and most often presents with unexpected bleeding. In contrast to congenital hemophilia, the …

Clinical evidence and safety profile of emicizumab for the management of children with hemophilia A

S Le Quellec - Drug Design, Development and Therapy, 2020 - Taylor & Francis
Emicizumab is a bispecific, humanized, monoclonal antibody mimicking the factor (F) VIII
cofactor activity in mediating the generation of FXa by FIXa in patients with hemophilia A …

[HTML][HTML] Cross‐reacting inhibitors against recombinant porcine factor VIII in acquired hemophilia A: data from the GTH‐AH 01/2010 Study

H Türkantoz, C Königs, P Knöbl, R Klamroth… - Journal of Thrombosis …, 2020 - Elsevier
Background Recombinant porcine factor VIII (rpFVIII, OBI‐1, susoctocog alfa) is used for the
treatment of acute bleeds in patients with acquired hemophilia A (AHA). Inhibitors in AHA …

[HTML][HTML] An anti‐factor IXa/factor X bispecific antibody, emicizumab, improves ex vivo coagulant potentials in plasma from patients with acquired hemophilia A

M Takeyama, K Nogami, T Matsumoto… - Journal of Thrombosis …, 2020 - Elsevier
Abstract Introduction Acquired hemophilia A (AHA) is caused by autoantibodies against
factor (F) VIII, and is characterized by severe, spontaneous bleeding, which can be life …

[HTML][HTML] Susoctocog-alfa (Obizur®) in the treatment of nine elderly patients with acquired haemophilia A: an Italian multicentre real world experience

E Zanon, S Pasca, A Borchiellini, C Lodigiani… - Blood …, 2020 - ncbi.nlm.nih.gov
Background In 2016, a new recombinant B-domain deleted porcine FVIII (rpFVIII) was
licensed in Italy for the treatment of acquired haemophilia A (AHA), but only a few cases of …

Recombinant porcine FVIII for bleed treatment in acquired hemophilia A: findings from a single-center, 18-patient cohort

P Ellsworth, SL Chen, RS Kasthuri, NS Key… - Blood …, 2020 - ashpublications.org
Acquired hemophilia A (AHA) is a rare bleeding disorder in which acquired autoantibodies
to endogenous factor VIII (FVIII) decrease FVIII activity and lead to a bleeding phenotype. A …

[HTML][HTML] Hemofilia adquirida

J García-Chávez, A Majluf-Cruz - Gaceta médica de México, 2020 - scielo.org.mx
La hemofilia adquirida (HA) es un trastorno hemostático autoinmune ocasionado por
autoanticuerpos dirigidos contra el factor VIII: C. En 52% de los casos, la causa se …