OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …

The presence of macrophages within the plaque is a defining hallmark of atherosclerosis.
Macrophages are exposed to various microenvironments such as oxidized lipids and …

Atherosclerotic lesion progression is associated with intimal calcification. The earliest lesion
that shows calcification is pathologic intimal thickening in which calcifications appear as …

Background The benefits of LDL cholesterol-lowering treatment for the prevention of
atherosclerotic cardiovascular disease are well established. However, the extent to which …

Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) have been
developed and improved as both diagnostic and guidance tools for interventional …

Aim Remnant cholesterol has been proposed to promote atherosclerotic cardiovascular
disease independent of low-density lipoprotein cholesterol, yet the underlying mechanisms …

Statins, widely prescribed for cardiovascular diseases, are also being eyed for management
of age-related macular degeneration (AMD). Poor bioavailability and blood-aqueous barrier …

Objective To evaluate whether biologic disease‐modifying antirheumatic drugs (DMARD s)
decrease cardiovascular disease (CVD) risk in rheumatoid arthritis (RA) and whether …

Atherosclerosis is a chronic progressive disease, which may result in serious clinical
outcomes, such as acute heart events or stroke with high mortality. At present, the clinical …

Background The addition of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor,
evolocumab, to statin therapy produced incremental regression of atherosclerotic plaques …