Wound healing: cellular mechanisms and pathological outcomes

HN Wilkinson, MJ Hardman - Open biology, 2020 - royalsocietypublishing.org
Wound healing is a complex, dynamic process supported by a myriad of cellular events that
must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound …

Macrophage mediation in normal and diabetic wound healing responses

GV Ganesh, KM Ramkumar - Inflammation Research, 2020 - Springer
Purpose The failure in timely healing of wounds is a central feature in chronic wounds that
leads to physiological, psychological and economic burdens. Macrophages have been …

Dual cross-linked HHA hydrogel supplies and regulates MΦ2 for synergistic improvement of immunocompromise and impaired angiogenesis to enhance diabetic …

S Liu, J Yu, Q Zhang, H Lu, X Qiu, D Zhou, Y Qi… - …, 2020 - ACS Publications
Immunocompromise and impaired angiogenesis of diabetes lead to chronic inflammation
when wounds occur, which is the primary reason for the long-term incurable nature of …

NLRP3 inflammasome activity is required for wound healing after burns

R Vinaik, A Abdullahi, D Barayan, MG Jeschke - Translational Research, 2020 - Elsevier
Survival of burn patients is contingent on effective wound healing, a complex process that
requires coordinated responses of myeloid cells and inflammatory pathways. NLRP3, which …

[HTML][HTML] The shift in macrophages polarisation after tendon injury: A systematic review

HT Xu, CW Lee, MY Li, YF Wang, PSH Yung… - Journal of Orthopaedic …, 2020 - Elsevier
Background The role of macrophages (Mφs) in tendon injury healing is controversy. The
aims of this study were to determine whether there is a shift in Mφs polarisation after an …

Annexin A1‐derived peptide Ac2‐26 facilitates wound healing in diabetic mice

JJ Huang, CJ Xia, Y Wei, Y Yao… - Wound Repair and …, 2020 - Wiley Online Library
Impaired wound healing is a common complication of diabetes. In diabetic wounds,
macrophages present dysfunctional efferocytosis and abnormal phenotypes, which could …

Photobiomodulation by dual-wavelength low-power laser effects on infected pressure ulcers

AMC Thome Lima, LP da Silva Sergio… - Lasers in medical …, 2020 - Springer
The aim of this study was to evaluate the effects of photobiomodulation (PBM) by dual-
wavelength low-power lasers on the healing and bacterial bioburden of pressure ulcer (PU) …

[HTML][HTML] Modulation of airway epithelial innate immunity and wound repair by M (GM-CSF) and M (M-CSF) macrophages

S van Riet, A van Schadewijk, S De Vos… - Journal of Innate …, 2020 - karger.com
Airway epithelial cells and macrophages participate in inflammatory responses to external
noxious stimuli, which can cause epithelial injury. Upon injury, epithelial cells and …

[HTML][HTML] Orf virus IL-10 and VEGF-E act synergistically to enhance healing of cutaneous wounds in mice

LM Wise, GS Stuart, NC Jones, SB Fleming… - Journal of Clinical …, 2020 - mdpi.com
Orf virus (OV) is a zoonotic parapoxvirus that causes highly proliferative skin lesions which
resolve with minimal inflammation and scarring. OV encodes two immunomodulators …

Controlling the phenotype of macrophages promotes maturation of tissue-engineered cartilage

Y Fujihara, T Abe, K Hoshi - Tissue Engineering Part A, 2020 - liebertpub.com
Tissue reactions after transplantation can affect the maturation and prognosis of the
transplanted engineered tissue in regenerative medicine. Since macrophages are broadly …