Human embryogenesis is hallmarked by two phases of yolk sac development. The primate
hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a …

Embryonic stem cells (ESCs) are derived from the pre-implantation mammalian blastocyst.
At this point in time, the newly formed embryo is concerned with the generation and …

Precise control and maintenance of population size is fundamental for organismal
development and homeostasis. The three cell types of the mammalian blastocyst are …

Pluripotent stem cells (PSCs) transition between cell states in vitro, reflecting developmental
changes in the early embryo. PSCs can be stabilized in the naive state by blocking …

Our understanding of the signalling pathways regulating early human development is
limited, despite their fundamental biological importance. Here, we mine transcriptomics …

FGF/ERK signaling is crucial for the patterning and proliferation of cell lineages that
comprise the mouse blastocyst. However, ERK signaling dynamics have never been directly …

Mouse embryonic stem cells (mESCs) cultured in the presence of LIF occupy a ground state
with highly active pluripotency-associated transcriptional and epigenetic circuitry. However …

Pre-implantation mammalian development unites extreme plasticity with a robust outcome:
the formation of a blastocyst, an organised multi-layered structure ready for implantation …

In ungulates, early embryonic development differs dramatically from that of mice and
humans and is characterized by an extended period of pre-and peri-implantation …

Early embryogenesis is characterized by the segregation of cell lineages that fulfill critical
roles in the establishment of pregnancy and development of the fetus. The formation of the …